Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states

Siva S Panda

doi:10.1039/c3ob27421g

Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states

Siva S Panda

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

Original language	English (US)
Pages (from-to)	1594-7
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	10
DOIs	https://doi.org/10.1039/c3ob27421g
State	Published - Feb 13 2013

Keywords

Acylation
Molecular Structure
Peptides
Stereoisomerism
Tryptophan
Journal Article

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10.1039/c3ob27421g

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title = "Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states",

abstract = "N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.",

keywords = "Acylation, Molecular Structure, Peptides, Stereoisomerism, Tryptophan, Journal Article",

author = "Panda, {Siva S}",

year = "2013",

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doi = "10.1039/c3ob27421g",

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AU - Panda, Siva S

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N2 - N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

AB - N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

KW - Acylation

KW - Molecular Structure

KW - Peptides

KW - Stereoisomerism

KW - Tryptophan

KW - Journal Article

U2 - 10.1039/c3ob27421g

DO - 10.1039/c3ob27421g

M3 - Article

C2 - 23361377

SN - 1477-0520

VL - 11

SP - 1594

EP - 1597

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 10

ER -

Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states

Abstract

Keywords

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