Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states

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15 Scopus citations

Abstract

N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

Original languageEnglish (US)
Pages (from-to)1594-7
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number10
DOIs
StatePublished - Feb 13 2013

Keywords

  • Acylation
  • Molecular Structure
  • Peptides
  • Stereoisomerism
  • Tryptophan
  • Journal Article

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