LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes

Xuhui Dong, Hua Yang, Xiangtian Zhou, Xiaoling Xie, Dongliang Yu, Luming Guo, Mei Xu, Wenjun Zhang, Guoqing Liang, Lin Gan

Research output: Contribution to journalArticlepeer-review

Abstract

Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.

Original languageEnglish (US)
Article number108144
JournalCell Reports
Volume32
Issue number11
DOIs
StatePublished - Sep 15 2020

Keywords

  • AII amacrine cells
  • ERG
  • GABAergic ACs
  • LIM-homeodomain transcription factor
  • congenital stationary night blindness
  • rod bipolar cells
  • rod-connecting CBCs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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