Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment

Wei Ma, Jing Ma, Jie Xu, Chong Qiao, Adam Branscum, Andres Cardenas, Andre T. Baron, Peter Schwartz, Nita J. Maihle, Yingqun Huang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has been shown to increase CSC proliferation and tumor growth. Here, we report that Lin28, a stem cell factor, binds to BMP4 mRNA in epithelial ovarian carcinoma cells, thereby promoting BMP4 expression at the post-transcriptional level. As co-expression of Lin28 and Oct4 (another stem cell factor) has been implicated in ovarian cancer CSCs, we also determined that high levels of Lin28 are associated with an unfavorable prognosis when co-expressed with high levels of Oct4. Together, these findings uncover a new level of regulation of BMP4 expression and imply a novel Lin28/Oct4/BMP4-mediated mechanism of regulating ovarian tumor cell growth, thus holding potential for the development of new strategies for the diagnosis and treatment of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)88-97
Number of pages10
JournalCell Cycle
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Tumor Microenvironment
Neoplastic Stem Cells
Ovarian Neoplasms
Stem Cell Factor
Autocrine Communication
Paracrine Communication
Neoplasms
Bone Morphogenetic Proteins
Growth
Cell Proliferation
Carcinoma
Messenger RNA

Keywords

  • BMP4
  • Lin28/Oct4
  • Ovarian cancer
  • Posttranscriptional
  • Tumor microenvironment

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Ma, W., Ma, J., Xu, J., Qiao, C., Branscum, A., Cardenas, A., ... Huang, Y. (2013). Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. Cell Cycle, 12(1), 88-97. https://doi.org/10.4161/cc.23028

Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. / Ma, Wei; Ma, Jing; Xu, Jie; Qiao, Chong; Branscum, Adam; Cardenas, Andres; Baron, Andre T.; Schwartz, Peter; Maihle, Nita J.; Huang, Yingqun.

In: Cell Cycle, Vol. 12, No. 1, 01.01.2013, p. 88-97.

Research output: Contribution to journalArticle

Ma, W, Ma, J, Xu, J, Qiao, C, Branscum, A, Cardenas, A, Baron, AT, Schwartz, P, Maihle, NJ & Huang, Y 2013, 'Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment', Cell Cycle, vol. 12, no. 1, pp. 88-97. https://doi.org/10.4161/cc.23028
Ma, Wei ; Ma, Jing ; Xu, Jie ; Qiao, Chong ; Branscum, Adam ; Cardenas, Andres ; Baron, Andre T. ; Schwartz, Peter ; Maihle, Nita J. ; Huang, Yingqun. / Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. In: Cell Cycle. 2013 ; Vol. 12, No. 1. pp. 88-97.
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