Linkage analysis of chromosome 14 and essential hypertension in Chinese population

Wei Yan Zhao, Jian Feng Huang, Dong Ilang Ge, Shaoyong Su, Biao Li, Dong Feng Gu

Research output: Contribution to journalArticle

Abstract

Background: Hypertension is a complex biological trait that influenced by multiple factors. The encouraging results for hypertension research showed that the linkage analysis can be used to replicate other studies and discover new genetic risk factors. Previous studies linked human chromosome 14 to essential hypertension or blood pressure traits. With a Chinese population, we tried to replicate these findings. Methods: A linkage scan was performed on chromosome 14 with 14-microsatellite markers with a density of about 10 centi Morgen (cM) in 147 Chinese hypertensive nuclear families. Multipoint non-parametric linkage analysis and exclusion mapping were performed with the GENEHUNTER software, whereas quantitative analysis was performed with the variance component method integrated in the SOLAR package. Results: In the qualitative analysis, the highest non-parametric linkage score is 1.0 (P=0.14) at D14S261 in the single point analysis, and no loci achieved non-parametric linkage score more than 1.0 in the multipoint analysis. Maximum-likelihood mapping showed no significant results, either. Subsequently the traditional exclusion criteria of the log-of-the-odds score-2 were adopted, and the chromosome 14 with ·s·2.4 was excluded. In the quantitative analysis of blood pressure with the SOLAR software, two-point analysis and multipoint analysis suggested no evidence for linkage occurred on chromosome 14 for systolic and diastolic blood pressure. Conclusion: There was no substantial evidence to support the linkage of chromosome 14 and essential hypertension or blood pressure trait in Chinese hypertensive subjects in this study.

Original languageEnglish (US)
Pages (from-to)1939-1944
Number of pages6
JournalChinese Medical Journal
Volume118
Issue number23
StatePublished - Dec 5 2005

Fingerprint

Chromosomes, Human, Pair 14
Blood Pressure
Population
Software
Hypertension
Human Chromosomes
Nuclear Family
Microsatellite Repeats
Essential Hypertension
Research

Keywords

  • Chinese
  • Chromosome 14
  • Essential hypertension
  • Linkage analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zhao, W. Y., Huang, J. F., Ge, D. I., Su, S., Li, B., & Gu, D. F. (2005). Linkage analysis of chromosome 14 and essential hypertension in Chinese population. Chinese Medical Journal, 118(23), 1939-1944.

Linkage analysis of chromosome 14 and essential hypertension in Chinese population. / Zhao, Wei Yan; Huang, Jian Feng; Ge, Dong Ilang; Su, Shaoyong; Li, Biao; Gu, Dong Feng.

In: Chinese Medical Journal, Vol. 118, No. 23, 05.12.2005, p. 1939-1944.

Research output: Contribution to journalArticle

Zhao, WY, Huang, JF, Ge, DI, Su, S, Li, B & Gu, DF 2005, 'Linkage analysis of chromosome 14 and essential hypertension in Chinese population', Chinese Medical Journal, vol. 118, no. 23, pp. 1939-1944.
Zhao, Wei Yan ; Huang, Jian Feng ; Ge, Dong Ilang ; Su, Shaoyong ; Li, Biao ; Gu, Dong Feng. / Linkage analysis of chromosome 14 and essential hypertension in Chinese population. In: Chinese Medical Journal. 2005 ; Vol. 118, No. 23. pp. 1939-1944.
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