Linkage analysis of schizophrenia in African-American families

H. W. Wiener, L. Klei, M. D. Irvin, R. T. Perry, M. H. Aliyu, T. B. Allen, L. D. Bradford, M. E. Calkins, B. Devlin, N. Edwards, R. E. Gur, R. C. Gur, J. Kwentus, P. D. Lyons, Joseph Patrick McEvoy, H. A. Nasrallah, V. L. Nimgaonkar, J. O'Jile, Alberto Santos, R. M. Savage & 1 others R. C.P. Go

Research output: Contribution to journalArticle

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Abstract

While many studies have sought a window into the genetics of schizophrenia, few have focused on African-American families. An exception is the Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS), which seeks to identify novel and known risk variation for schizophrenia by genetic analyses of African-American families. We report a linkage study of diagnostic status in 217 African-American families using the Illumina Linkage Panel. Due to assumed incomplete and time-dependent penetrance, we performed linkage analysis using two different treatments of diagnosis: (1) treating both affected and unaffected individuals as informative for linkage (using the program SIBPAL) and (2) treating only affected individuals as informative (using the program MERLIN). We also explore three definitions of affected status: narrowly defined schizophrenia; one broadened to include schizoaffective disorder; and another including all diagnoses indicating psychosis. Several regions show a decrease in the evidence for linkage as the definition broadens 8q22.1 (rs911, 99.26 cM; SIBPAL p-value [p] goes from 0.006 to 0.02), 16q24.3 (rs1006547, 130.48 cM; p from 0.00095 to 0.0085), and 20q13.2 (rs1022689, 81.73 cM; p from 0.00015 to 0.032). One region shows a substantial increase in evidence for linkage, 11p15.2 (rs722317, 24.27 cM; p from 0.0022 to 0.0000003); MERLIN results support the significance of the SIBPAL results (p = 0.00001). Our linkage results overlap two broad, previously-reported linkage regions: 8p23.3-p12 found in studies sampling largely families of European ancestry; and 11p11.2-q22.3 reported by a study of African-American families. These results should prove quite useful for uncovering loci affecting risk for schizophrenia.

Original languageEnglish (US)
Pages (from-to)70-79
Number of pages10
JournalSchizophrenia Research
Volume109
Issue number1-3
DOIs
StatePublished - Apr 1 2009

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African Americans
Schizophrenia
Psychotic Disorders
Sampling Studies
Penetrance
Therapeutics

Keywords

  • African-American
  • Linkage
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Wiener, H. W., Klei, L., Irvin, M. D., Perry, R. T., Aliyu, M. H., Allen, T. B., ... Go, R. C. P. (2009). Linkage analysis of schizophrenia in African-American families. Schizophrenia Research, 109(1-3), 70-79. https://doi.org/10.1016/j.schres.2009.02.007

Linkage analysis of schizophrenia in African-American families. / Wiener, H. W.; Klei, L.; Irvin, M. D.; Perry, R. T.; Aliyu, M. H.; Allen, T. B.; Bradford, L. D.; Calkins, M. E.; Devlin, B.; Edwards, N.; Gur, R. E.; Gur, R. C.; Kwentus, J.; Lyons, P. D.; McEvoy, Joseph Patrick; Nasrallah, H. A.; Nimgaonkar, V. L.; O'Jile, J.; Santos, Alberto; Savage, R. M.; Go, R. C.P.

In: Schizophrenia Research, Vol. 109, No. 1-3, 01.04.2009, p. 70-79.

Research output: Contribution to journalArticle

Wiener, HW, Klei, L, Irvin, MD, Perry, RT, Aliyu, MH, Allen, TB, Bradford, LD, Calkins, ME, Devlin, B, Edwards, N, Gur, RE, Gur, RC, Kwentus, J, Lyons, PD, McEvoy, JP, Nasrallah, HA, Nimgaonkar, VL, O'Jile, J, Santos, A, Savage, RM & Go, RCP 2009, 'Linkage analysis of schizophrenia in African-American families', Schizophrenia Research, vol. 109, no. 1-3, pp. 70-79. https://doi.org/10.1016/j.schres.2009.02.007
Wiener HW, Klei L, Irvin MD, Perry RT, Aliyu MH, Allen TB et al. Linkage analysis of schizophrenia in African-American families. Schizophrenia Research. 2009 Apr 1;109(1-3):70-79. https://doi.org/10.1016/j.schres.2009.02.007
Wiener, H. W. ; Klei, L. ; Irvin, M. D. ; Perry, R. T. ; Aliyu, M. H. ; Allen, T. B. ; Bradford, L. D. ; Calkins, M. E. ; Devlin, B. ; Edwards, N. ; Gur, R. E. ; Gur, R. C. ; Kwentus, J. ; Lyons, P. D. ; McEvoy, Joseph Patrick ; Nasrallah, H. A. ; Nimgaonkar, V. L. ; O'Jile, J. ; Santos, Alberto ; Savage, R. M. ; Go, R. C.P. / Linkage analysis of schizophrenia in African-American families. In: Schizophrenia Research. 2009 ; Vol. 109, No. 1-3. pp. 70-79.
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