Lipid rafts in neuregulin signaling at synapses

Xiao Li Yang, Wen C. Xiong, Lin Mei

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Neuregulins are a family of EGF domain-containing factors that play an important role in development. In the nervous system, they promote glial differentiation, induce neurotransmitter receptor expression, and regulate synaptic plasticity. Recent studies indicate that ErbB protein tyrosine kinases, neuregulin receptors, translocate to lipid raft microdomains in the plasma membrane in response to neuregulin. Localization of ErbB proteins in lipid rafts appeared to be necessary for neuregulin signaling and regulation of synaptic plasticity. We will review recent studies of lipid rafts and neuregulin function and discuss possible roles of lipid rafts in compartmentalized neuregulin signaling and translocation of ErbB proteins to synapses.

Original languageEnglish (US)
Pages (from-to)2495-2504
Number of pages10
JournalLife sciences
Volume75
Issue number21
DOIs
StatePublished - Oct 8 2004

Keywords

  • ErbB
  • Lipid rafts
  • Microdomains
  • Neuregulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Yang, X. L., Xiong, W. C., & Mei, L. (2004). Lipid rafts in neuregulin signaling at synapses. Life sciences, 75(21), 2495-2504. https://doi.org/10.1016/j.lfs.2004.04.036