Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: Case report

Cargill H. Alleyne; Steve Hunter; Jeffrey J. Oison; Daniel L. Barrow

doi:10.1097/00006123-199803000-00035

Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: Case report

Cargill H. Alleyne, Steve Hunter, Jeffrey J. Oison, Daniel L. Barrow

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

OBJECTIVE AND IMPORTANCE: We report a case of posterior fossa neuroepithelial tumor with unusual clinical presentation, magnetic resonance imaging appearance, and morphological features. CLINICAL PRESENTATION: This 66-year-old man presented with a history of gait ataxia, dizziness, and tinnitus and was found to have a large tumor in the posterior fossa and cerebellopontine angle. INTERVENTION: Gross total excision of the tumor was accomplished. Histologically, the most unique features were macrovesicular accumulations of lipid, giving the tumor (at least focally) an appearance virtually identical to that of mature adipose tissue. Evidence of biphasic neuronal and glial differentiation was noted by immunohistochemistry and electron microscopy. CONCLUSION: A literature review is presented. Diagnostically, this neoplasm seems to fit in a unique group of rarely described, lipomatous neuroectodermal tumors that show divergent neuronal and glial differentiation.

Original language	English (US)
Pages (from-to)	639-643
Number of pages	5
Journal	Neurosurgery
Volume	42
Issue number	3
DOIs	https://doi.org/10.1097/00006123-199803000-00035
State	Published - Mar 1998
Externally published	Yes

Keywords

Adipose tissue
Ectomesoderm
Lipomatous differentiation
Neurocytoma
Posterior fossa tumors
Synaptophysin

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1097/00006123-199803000-00035

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title = "Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: Case report",

abstract = "OBJECTIVE AND IMPORTANCE: We report a case of posterior fossa neuroepithelial tumor with unusual clinical presentation, magnetic resonance imaging appearance, and morphological features. CLINICAL PRESENTATION: This 66-year-old man presented with a history of gait ataxia, dizziness, and tinnitus and was found to have a large tumor in the posterior fossa and cerebellopontine angle. INTERVENTION: Gross total excision of the tumor was accomplished. Histologically, the most unique features were macrovesicular accumulations of lipid, giving the tumor (at least focally) an appearance virtually identical to that of mature adipose tissue. Evidence of biphasic neuronal and glial differentiation was noted by immunohistochemistry and electron microscopy. CONCLUSION: A literature review is presented. Diagnostically, this neoplasm seems to fit in a unique group of rarely described, lipomatous neuroectodermal tumors that show divergent neuronal and glial differentiation.",

keywords = "Adipose tissue, Ectomesoderm, Lipomatous differentiation, Neurocytoma, Posterior fossa tumors, Synaptophysin",

author = "Alleyne, {Cargill H.} and Steve Hunter and Oison, {Jeffrey J.} and Barrow, {Daniel L.}",

year = "1998",

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T2 - Case report

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AU - Hunter, Steve

AU - Oison, Jeffrey J.

AU - Barrow, Daniel L.

PY - 1998/3

Y1 - 1998/3

N2 - OBJECTIVE AND IMPORTANCE: We report a case of posterior fossa neuroepithelial tumor with unusual clinical presentation, magnetic resonance imaging appearance, and morphological features. CLINICAL PRESENTATION: This 66-year-old man presented with a history of gait ataxia, dizziness, and tinnitus and was found to have a large tumor in the posterior fossa and cerebellopontine angle. INTERVENTION: Gross total excision of the tumor was accomplished. Histologically, the most unique features were macrovesicular accumulations of lipid, giving the tumor (at least focally) an appearance virtually identical to that of mature adipose tissue. Evidence of biphasic neuronal and glial differentiation was noted by immunohistochemistry and electron microscopy. CONCLUSION: A literature review is presented. Diagnostically, this neoplasm seems to fit in a unique group of rarely described, lipomatous neuroectodermal tumors that show divergent neuronal and glial differentiation.

AB - OBJECTIVE AND IMPORTANCE: We report a case of posterior fossa neuroepithelial tumor with unusual clinical presentation, magnetic resonance imaging appearance, and morphological features. CLINICAL PRESENTATION: This 66-year-old man presented with a history of gait ataxia, dizziness, and tinnitus and was found to have a large tumor in the posterior fossa and cerebellopontine angle. INTERVENTION: Gross total excision of the tumor was accomplished. Histologically, the most unique features were macrovesicular accumulations of lipid, giving the tumor (at least focally) an appearance virtually identical to that of mature adipose tissue. Evidence of biphasic neuronal and glial differentiation was noted by immunohistochemistry and electron microscopy. CONCLUSION: A literature review is presented. Diagnostically, this neoplasm seems to fit in a unique group of rarely described, lipomatous neuroectodermal tumors that show divergent neuronal and glial differentiation.

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KW - Posterior fossa tumors

KW - Synaptophysin

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Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: Case report

Abstract

Keywords

ASJC Scopus subject areas

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