Abstract
Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4710-4722 |
| Number of pages | 13 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 21 2014 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA. / Rafikov, Ruslan; Dimitropoulou, Christiana; Aggarwal, Saurabh; Kangath, Archana; Gross, Christine; Pardo, Daniel; Sharma, Shruti; Jezierska-Drutel, Agnieszka; Patel, Vijaykumar Surendrakant; Snead, Connie; Lucas, Rudolf; Verin, Alexander Dmitriyevich; Fulton, David J; Catravas, John D.; Black, Stephen Matthew.
In: Journal of Biological Chemistry, Vol. 289, No. 8, 21.02.2014, p. 4710-4722.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA
AU - Rafikov, Ruslan
AU - Dimitropoulou, Christiana
AU - Aggarwal, Saurabh
AU - Kangath, Archana
AU - Gross, Christine
AU - Pardo, Daniel
AU - Sharma, Shruti
AU - Jezierska-Drutel, Agnieszka
AU - Patel, Vijaykumar Surendrakant
AU - Snead, Connie
AU - Lucas, Rudolf
AU - Verin, Alexander Dmitriyevich
AU - Fulton, David J
AU - Catravas, John D.
AU - Black, Stephen Matthew
PY - 2014/2/21
Y1 - 2014/2/21
N2 - Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
AB - Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
UR - http://www.scopus.com/inward/record.url?scp=84896699089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896699089&partnerID=8YFLogxK
U2 - 10.1074/jbc.M114.547596
DO - 10.1074/jbc.M114.547596
M3 - Article
C2 - 24398689
AN - SCOPUS:84896699089
VL - 289
SP - 4710
EP - 4722
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 8
ER -