TY - JOUR
T1 - Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA
AU - Rafikov, Ruslan
AU - Dimitropoulou, Christiana
AU - Aggarwal, Saurabh
AU - Kangath, Archana
AU - Gross, Christine
AU - Pardo, Daniel
AU - Sharma, Shruti
AU - Jezierska-Drutel, Agnieszka
AU - Patel, Vijay
AU - Snead, Connie
AU - Lucas, Rudolf
AU - Verin, Alexander
AU - Fulton, David
AU - Catravas, John D.
AU - Black, Stephen M.
PY - 2014/2/21
Y1 - 2014/2/21
N2 - Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
AB - Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
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U2 - 10.1074/jbc.M114.547596
DO - 10.1074/jbc.M114.547596
M3 - Article
C2 - 24398689
AN - SCOPUS:84896699089
VL - 289
SP - 4710
EP - 4722
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 8
ER -