Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA

Ruslan Rafikov, Christiana Dimitropoulou, Saurabh Aggarwal, Archana Kangath, Christine Gross, Daniel Pardo, Shruti Sharma, Agnieszka Jezierska-Drutel, Vijay Patel, Connie Snead, Rudolf Lucas, Alexander Verin, David Fulton, John D. Catravas, Stephen M. Black

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.

Original languageEnglish (US)
Pages (from-to)4710-4722
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Rafikov, R., Dimitropoulou, C., Aggarwal, S., Kangath, A., Gross, C., Pardo, D., Sharma, S., Jezierska-Drutel, A., Patel, V., Snead, C., Lucas, R., Verin, A., Fulton, D., Catravas, J. D., & Black, S. M. (2014). Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA. Journal of Biological Chemistry, 289(8), 4710-4722. https://doi.org/10.1074/jbc.M114.547596