Abstract
Background: The activation of RhoA is a critical event in acute lung injury (ALI), but the role of nitration in this process is unresolved. Results: The nitration of RhoA at Tyr34 produced GEF-like conformational changes that stimulate RhoA by decreasing GDP binding. Conclusion: We have identified a new mechanism of RhoA activation. Significance: Preventing RhoA nitration may be useful for the management of ALI.
Original language | English (US) |
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Pages (from-to) | 4710-4722 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 8 |
DOIs | |
State | Published - Feb 21 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology