Lipoproteins and lipid peroxidation in Alzheimer's Disease

Casey Bassett, Thomas J. Montine

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Alzheimer's Disease (AD) is a clinical-pathological entity that probably derives from different causes. Mounting evidence strongly implicates regionally increased oxidative damage to brain beyond what occurs with aging as one of the processes that may contribute to AD progression. While several different classes of molecules may be affected, lipid peroxidation is thought to be a prominent and especially deleterious form of oxidative damage in brain due to this organ's relative enrichment in polyunsaturated fatty acids. Our laboratory recently has demonstrated that lipoproteins in AD brain extracellular fluid are more vulnerable to oxidation than lipoproteins in control brain extracellular fluid. Apolipoprotein E (apoE) is the principal apolipoprotein in the central nervous system (CNS), and it serves as the major apolipoprotein that is capable of lipid transport and regulation of lipid metabolism through known receptor-mediated processes. Moreover, inheritance of the APOE4 allele represents the strongest genetic risk factor for sporadic AD. Evidence suggests that apoE isoforms may specifically influence the cellular distribution of lipid peroxidation products in brain and may therefore contribute to the stratification of risk for AD associated with APOE. Here, we review possible mechanisms whereby lipoprotein trafficking and lipid peroxidation converge to contribute to neurodegeneration in AD brain.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalJournal of Nutrition, Health and Aging
Volume7
Issue number1
StatePublished - Mar 6 2003
Externally publishedYes

Fingerprint

Lipid Peroxidation
Lipoproteins
Alzheimer Disease
Brain
Apolipoproteins
Extracellular Fluid
Apolipoproteins E
Unsaturated Fatty Acids
Lipid Metabolism
Disease Progression
Protein Isoforms
Central Nervous System
Alleles
Lipids

Keywords

  • Aging
  • Alzheimer's disease
  • ApoE
  • Elderly
  • Lipid peroxidation
  • Lipoproteins
  • Neurodegeneration
  • Nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Lipoproteins and lipid peroxidation in Alzheimer's Disease. / Bassett, Casey; Montine, Thomas J.

In: Journal of Nutrition, Health and Aging, Vol. 7, No. 1, 06.03.2003, p. 24-29.

Research output: Contribution to journalArticle

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