Liver enzymes and clustering cardiometabolic risk factors in European adolescents

The HELENA study

I. Labayen, J. R. Ruiz, F. B. Ortega, Catherine Lucy Davis, G. Rodríguez, M. González-Gross, C. Breidenassel, J. Dallongeville, A. Marcos, K. Widhalm, A. Kafatos, D. Molnar, S. Dehenauw, F. Gottrand, L. A. Moreno

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives This study aimed to explore the associations of liver biomarkers with cardiometabolic risk factors and their clustering, and to provide reference values (percentiles) and cut-off points for liver biomarkers associated with high cardiometabolic risk in European adolescents. Methods Alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate aminotransferase to ALT ratio (AST/ALT), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin were measured in 1084 adolescents. We computed a continuous cardiometabolic risk score and defined the high cardiometabolic risk. Results Higher ALT and GGT and lower AST/ALT were associated with adiposity and with the number of adverse cardiometabolic risk factors (Ps < 0.05). Higher GGT and lower AST/ALT were associated with higher cardiometabolic risk score (Ps < 0.001) in males and females, and ALT only in males (Ps < 0.001). Gender- and age-specific percentiles for liver biomarkers were provided. Receiver operating characteristic analyses showed a significant discriminatory accuracy of AST/ALT in identifying the low/high cardiometabolic risk (Ps < 0.01) and thresholds were provided. Conclusions Higher GGT and lower AST/ALT are associated with higher cardiometabolic risk factors and their clustering in male and female European adolescents, whereas the associations of ALT were gender dependent. Our results suggest the usefulness of AST/ALT as a screening test in the assessment of adolescents with high cardiometabolic risk and provide gender- and age-specific thresholds that might be of clinical interest.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalPediatric obesity
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2015

Fingerprint

Cluster Analysis
Transaminases
Alanine Transaminase
gamma-Glutamyltransferase
Liver
Enzymes
Biomarkers
Adiposity
Waist Circumference
Aspartate Aminotransferases
ROC Curve
HDL Cholesterol
Reference Values
Triglycerides
Insulin
Blood Pressure

Keywords

  • Liver
  • adolescents
  • cardiometabolic risk factors
  • obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Labayen, I., Ruiz, J. R., Ortega, F. B., Davis, C. L., Rodríguez, G., González-Gross, M., ... Moreno, L. A. (2015). Liver enzymes and clustering cardiometabolic risk factors in European adolescents: The HELENA study. Pediatric obesity, 10(5), 361-370. https://doi.org/10.1111/ijpo.273

Liver enzymes and clustering cardiometabolic risk factors in European adolescents : The HELENA study. / Labayen, I.; Ruiz, J. R.; Ortega, F. B.; Davis, Catherine Lucy; Rodríguez, G.; González-Gross, M.; Breidenassel, C.; Dallongeville, J.; Marcos, A.; Widhalm, K.; Kafatos, A.; Molnar, D.; Dehenauw, S.; Gottrand, F.; Moreno, L. A.

In: Pediatric obesity, Vol. 10, No. 5, 01.10.2015, p. 361-370.

Research output: Contribution to journalArticle

Labayen, I, Ruiz, JR, Ortega, FB, Davis, CL, Rodríguez, G, González-Gross, M, Breidenassel, C, Dallongeville, J, Marcos, A, Widhalm, K, Kafatos, A, Molnar, D, Dehenauw, S, Gottrand, F & Moreno, LA 2015, 'Liver enzymes and clustering cardiometabolic risk factors in European adolescents: The HELENA study', Pediatric obesity, vol. 10, no. 5, pp. 361-370. https://doi.org/10.1111/ijpo.273
Labayen, I. ; Ruiz, J. R. ; Ortega, F. B. ; Davis, Catherine Lucy ; Rodríguez, G. ; González-Gross, M. ; Breidenassel, C. ; Dallongeville, J. ; Marcos, A. ; Widhalm, K. ; Kafatos, A. ; Molnar, D. ; Dehenauw, S. ; Gottrand, F. ; Moreno, L. A. / Liver enzymes and clustering cardiometabolic risk factors in European adolescents : The HELENA study. In: Pediatric obesity. 2015 ; Vol. 10, No. 5. pp. 361-370.
@article{2636e609bfa2401fb8d11efd0f632c0e,
title = "Liver enzymes and clustering cardiometabolic risk factors in European adolescents: The HELENA study",
abstract = "Objectives This study aimed to explore the associations of liver biomarkers with cardiometabolic risk factors and their clustering, and to provide reference values (percentiles) and cut-off points for liver biomarkers associated with high cardiometabolic risk in European adolescents. Methods Alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate aminotransferase to ALT ratio (AST/ALT), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin were measured in 1084 adolescents. We computed a continuous cardiometabolic risk score and defined the high cardiometabolic risk. Results Higher ALT and GGT and lower AST/ALT were associated with adiposity and with the number of adverse cardiometabolic risk factors (Ps < 0.05). Higher GGT and lower AST/ALT were associated with higher cardiometabolic risk score (Ps < 0.001) in males and females, and ALT only in males (Ps < 0.001). Gender- and age-specific percentiles for liver biomarkers were provided. Receiver operating characteristic analyses showed a significant discriminatory accuracy of AST/ALT in identifying the low/high cardiometabolic risk (Ps < 0.01) and thresholds were provided. Conclusions Higher GGT and lower AST/ALT are associated with higher cardiometabolic risk factors and their clustering in male and female European adolescents, whereas the associations of ALT were gender dependent. Our results suggest the usefulness of AST/ALT as a screening test in the assessment of adolescents with high cardiometabolic risk and provide gender- and age-specific thresholds that might be of clinical interest.",
keywords = "Liver, adolescents, cardiometabolic risk factors, obesity",
author = "I. Labayen and Ruiz, {J. R.} and Ortega, {F. B.} and Davis, {Catherine Lucy} and G. Rodr{\'i}guez and M. Gonz{\'a}lez-Gross and C. Breidenassel and J. Dallongeville and A. Marcos and K. Widhalm and A. Kafatos and D. Molnar and S. Dehenauw and F. Gottrand and Moreno, {L. A.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1111/ijpo.273",
language = "English (US)",
volume = "10",
pages = "361--370",
journal = "Pediatric obesity",
issn = "2047-6310",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "5",

}

TY - JOUR

T1 - Liver enzymes and clustering cardiometabolic risk factors in European adolescents

T2 - The HELENA study

AU - Labayen, I.

AU - Ruiz, J. R.

AU - Ortega, F. B.

AU - Davis, Catherine Lucy

AU - Rodríguez, G.

AU - González-Gross, M.

AU - Breidenassel, C.

AU - Dallongeville, J.

AU - Marcos, A.

AU - Widhalm, K.

AU - Kafatos, A.

AU - Molnar, D.

AU - Dehenauw, S.

AU - Gottrand, F.

AU - Moreno, L. A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objectives This study aimed to explore the associations of liver biomarkers with cardiometabolic risk factors and their clustering, and to provide reference values (percentiles) and cut-off points for liver biomarkers associated with high cardiometabolic risk in European adolescents. Methods Alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate aminotransferase to ALT ratio (AST/ALT), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin were measured in 1084 adolescents. We computed a continuous cardiometabolic risk score and defined the high cardiometabolic risk. Results Higher ALT and GGT and lower AST/ALT were associated with adiposity and with the number of adverse cardiometabolic risk factors (Ps < 0.05). Higher GGT and lower AST/ALT were associated with higher cardiometabolic risk score (Ps < 0.001) in males and females, and ALT only in males (Ps < 0.001). Gender- and age-specific percentiles for liver biomarkers were provided. Receiver operating characteristic analyses showed a significant discriminatory accuracy of AST/ALT in identifying the low/high cardiometabolic risk (Ps < 0.01) and thresholds were provided. Conclusions Higher GGT and lower AST/ALT are associated with higher cardiometabolic risk factors and their clustering in male and female European adolescents, whereas the associations of ALT were gender dependent. Our results suggest the usefulness of AST/ALT as a screening test in the assessment of adolescents with high cardiometabolic risk and provide gender- and age-specific thresholds that might be of clinical interest.

AB - Objectives This study aimed to explore the associations of liver biomarkers with cardiometabolic risk factors and their clustering, and to provide reference values (percentiles) and cut-off points for liver biomarkers associated with high cardiometabolic risk in European adolescents. Methods Alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate aminotransferase to ALT ratio (AST/ALT), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin were measured in 1084 adolescents. We computed a continuous cardiometabolic risk score and defined the high cardiometabolic risk. Results Higher ALT and GGT and lower AST/ALT were associated with adiposity and with the number of adverse cardiometabolic risk factors (Ps < 0.05). Higher GGT and lower AST/ALT were associated with higher cardiometabolic risk score (Ps < 0.001) in males and females, and ALT only in males (Ps < 0.001). Gender- and age-specific percentiles for liver biomarkers were provided. Receiver operating characteristic analyses showed a significant discriminatory accuracy of AST/ALT in identifying the low/high cardiometabolic risk (Ps < 0.01) and thresholds were provided. Conclusions Higher GGT and lower AST/ALT are associated with higher cardiometabolic risk factors and their clustering in male and female European adolescents, whereas the associations of ALT were gender dependent. Our results suggest the usefulness of AST/ALT as a screening test in the assessment of adolescents with high cardiometabolic risk and provide gender- and age-specific thresholds that might be of clinical interest.

KW - Liver

KW - adolescents

KW - cardiometabolic risk factors

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=84941599843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941599843&partnerID=8YFLogxK

U2 - 10.1111/ijpo.273

DO - 10.1111/ijpo.273

M3 - Article

VL - 10

SP - 361

EP - 370

JO - Pediatric obesity

JF - Pediatric obesity

SN - 2047-6310

IS - 5

ER -