Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice

Richard A. Mcindoe, Beverly Bohlman, Emil Chi, Eugene Schuster, Molly Lindhardt, Leroy Hood

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

One approach to understanding common human diseases is to determine the genetic defects responsible for similar diseases in animal models and place those defective genes in their corresponding biochemical pathways. Our laboratory is working with an animal model for human rheumatoid arthritis called collagen-induced arthritis (CIA). We are particularly interested in determining the location of disease-predisposing loci. To that end, we performed experiments to localize susceptibility loci for CIA in an F2 cross between the highly susceptible mouse strain DBA/1j and the highly resistant mouse Strain SWR/j. Specifically, a quantitative trait locus analysis was performed to localize regions of the mouse genome responsible for susceptibility/seVerity to CIA. One susceptibility locus, Cia1 in the major histocompatibility locus, had been identified previously. Two additional loci were detected in our analysis that contribute to CIA severity (Cia2, Cia3) on chromosomes 2 and 6. A third locus was detected that contributes to the age of onset of the disease. This locus (Cia4) was located on chromosome 2 and was linked to the same region as Cia2. Determining the identity of these loci may provide insights into the etiology of human rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)2210-2214
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number5
DOIs
StatePublished - Mar 2 1999
Externally publishedYes

Keywords

  • Collagen-induced arthritis
  • Genome scan
  • Rheumatoid

ASJC Scopus subject areas

  • General

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