Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells

Takeshi Chiyomaru, Shinichiro Fukuhara, Sharanjot Saini, Shahana Majid, Guoren Deng, Varahram Shahryari, Inik Chang, Yuichiro Tanaka, Hideki Enokida, Masayuki Nakagawa, Rajvir Dahiya, Soichiro Yamamura

Research output: Contribution to journalArticle

Abstract

Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions.

Original languageEnglish (US)
Pages (from-to)12550-12565
Number of pages16
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Long Noncoding RNA
MicroRNAs
Cells
Gene expression
Neoplasms
Gene Expression

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Chiyomaru, T., Fukuhara, S., Saini, S., Majid, S., Deng, G., Shahryari, V., ... Yamamura, S. (2014). Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells. Journal of Biological Chemistry, 289(18), 12550-12565. https://doi.org/10.1074/jbc.M113.488593

Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells. / Chiyomaru, Takeshi; Fukuhara, Shinichiro; Saini, Sharanjot; Majid, Shahana; Deng, Guoren; Shahryari, Varahram; Chang, Inik; Tanaka, Yuichiro; Enokida, Hideki; Nakagawa, Masayuki; Dahiya, Rajvir; Yamamura, Soichiro.

In: Journal of Biological Chemistry, Vol. 289, No. 18, 01.01.2014, p. 12550-12565.

Research output: Contribution to journalArticle

Chiyomaru, T, Fukuhara, S, Saini, S, Majid, S, Deng, G, Shahryari, V, Chang, I, Tanaka, Y, Enokida, H, Nakagawa, M, Dahiya, R & Yamamura, S 2014, 'Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells', Journal of Biological Chemistry, vol. 289, no. 18, pp. 12550-12565. https://doi.org/10.1074/jbc.M113.488593
Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V et al. Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells. Journal of Biological Chemistry. 2014 Jan 1;289(18):12550-12565. https://doi.org/10.1074/jbc.M113.488593
Chiyomaru, Takeshi ; Fukuhara, Shinichiro ; Saini, Sharanjot ; Majid, Shahana ; Deng, Guoren ; Shahryari, Varahram ; Chang, Inik ; Tanaka, Yuichiro ; Enokida, Hideki ; Nakagawa, Masayuki ; Dahiya, Rajvir ; Yamamura, Soichiro. / Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 18. pp. 12550-12565.
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