Long non-coding RNAs as master regulators in cardiovascular diseases

Krystal Archer, Zuzana Broskova, Ahmed S. Bayoumi, Jian Peng Teoh, Alec Davila, Yaoliang Tang, Huabo Su, Il Man Kim

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the link between heart disease and novel therapeutic targets such as non-coding RNAs. Among multiple non-coding RNAs, long non-coding RNA (lncRNA) has emerged as a novel therapeutic in cardiovascular medicine. LncRNAs are endogenous RNAs that contain over 200 nucleotides and regulate gene expression. Recent studies suggest critical roles of lncRNAs in modulating the initiation and progression of cardiovascular diseases. For example, aberrant lncRNA expression has been associated with the pathogenesis of ischemic heart failure. In this article, we present a synopsis of recent discoveries that link the roles and molecular interactions of lncRNAs to cardiovascular diseases. Moreover, we describe the prevalence of circulating lncRNAs and assess their potential utilities as biomarkers for diagnosis and prognosis of heart disease.

Original languageEnglish (US)
Pages (from-to)23651-23667
Number of pages17
JournalInternational journal of molecular sciences
Volume16
Issue number10
DOIs
StatePublished - Oct 5 2015

Keywords

  • Chromatin
  • Epigenetic regulation
  • Gene regulation
  • Heart disease
  • Non-coding RNAs

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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