Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys

Zhiyong Yang, David J. Heeger, Randolph Blake, Eyal Seidemann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Traveling waves of cortical activity, in which local stimulation triggers lateral spread of activity to distal locations, have been hypothesized to play an important role in cortical function. However, there is conflicting physiological evidence for the existence of spreading traveling waves of neural activity triggered locally. Dichoptic stimulation, in which the two eyes view dissimilar monocular patterns, can lead to dynamic wave-like fluctuations in visual perception and therefore, provides a promising means for identifying and studying cortical traveling waves. Here, we used voltage-sensitive dye imaging to test for the existence of traveling waves of activity in the primary visual cortex of awake, fixating monkeys viewing dichoptic stimuli. We find clear traveling waves that are initiated by brief, localized contrast increments in one of the monocular patterns and then, propagate at speeds of _30 mm/s. These results demonstrate that under an appropriate visual context, circuitry in visual cortex in alert animals is capable of supporting long-range traveling waves triggered by local stimulation.

Original languageEnglish (US)
Pages (from-to)277-294
Number of pages18
JournalJournal of Neurophysiology
Volume113
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Visual Cortex
Haplorhini
Voltage-Sensitive Dye Imaging
Visual Perception

Keywords

  • Dichoptic stimuli
  • Traveling wave
  • Visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys. / Yang, Zhiyong; Heeger, David J.; Blake, Randolph; Seidemann, Eyal.

In: Journal of Neurophysiology, Vol. 113, No. 1, 01.01.2015, p. 277-294.

Research output: Contribution to journalArticle

Yang, Zhiyong ; Heeger, David J. ; Blake, Randolph ; Seidemann, Eyal. / Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys. In: Journal of Neurophysiology. 2015 ; Vol. 113, No. 1. pp. 277-294.
@article{0aa0cc01ea434a5eb6930cae152a33a8,
title = "Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys",
abstract = "Traveling waves of cortical activity, in which local stimulation triggers lateral spread of activity to distal locations, have been hypothesized to play an important role in cortical function. However, there is conflicting physiological evidence for the existence of spreading traveling waves of neural activity triggered locally. Dichoptic stimulation, in which the two eyes view dissimilar monocular patterns, can lead to dynamic wave-like fluctuations in visual perception and therefore, provides a promising means for identifying and studying cortical traveling waves. Here, we used voltage-sensitive dye imaging to test for the existence of traveling waves of activity in the primary visual cortex of awake, fixating monkeys viewing dichoptic stimuli. We find clear traveling waves that are initiated by brief, localized contrast increments in one of the monocular patterns and then, propagate at speeds of _30 mm/s. These results demonstrate that under an appropriate visual context, circuitry in visual cortex in alert animals is capable of supporting long-range traveling waves triggered by local stimulation.",
keywords = "Dichoptic stimuli, Traveling wave, Visual cortex",
author = "Zhiyong Yang and Heeger, {David J.} and Randolph Blake and Eyal Seidemann",
year = "2015",
month = "1",
day = "1",
doi = "10.1152/jn.00610.2013",
language = "English (US)",
volume = "113",
pages = "277--294",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys

AU - Yang, Zhiyong

AU - Heeger, David J.

AU - Blake, Randolph

AU - Seidemann, Eyal

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Traveling waves of cortical activity, in which local stimulation triggers lateral spread of activity to distal locations, have been hypothesized to play an important role in cortical function. However, there is conflicting physiological evidence for the existence of spreading traveling waves of neural activity triggered locally. Dichoptic stimulation, in which the two eyes view dissimilar monocular patterns, can lead to dynamic wave-like fluctuations in visual perception and therefore, provides a promising means for identifying and studying cortical traveling waves. Here, we used voltage-sensitive dye imaging to test for the existence of traveling waves of activity in the primary visual cortex of awake, fixating monkeys viewing dichoptic stimuli. We find clear traveling waves that are initiated by brief, localized contrast increments in one of the monocular patterns and then, propagate at speeds of _30 mm/s. These results demonstrate that under an appropriate visual context, circuitry in visual cortex in alert animals is capable of supporting long-range traveling waves triggered by local stimulation.

AB - Traveling waves of cortical activity, in which local stimulation triggers lateral spread of activity to distal locations, have been hypothesized to play an important role in cortical function. However, there is conflicting physiological evidence for the existence of spreading traveling waves of neural activity triggered locally. Dichoptic stimulation, in which the two eyes view dissimilar monocular patterns, can lead to dynamic wave-like fluctuations in visual perception and therefore, provides a promising means for identifying and studying cortical traveling waves. Here, we used voltage-sensitive dye imaging to test for the existence of traveling waves of activity in the primary visual cortex of awake, fixating monkeys viewing dichoptic stimuli. We find clear traveling waves that are initiated by brief, localized contrast increments in one of the monocular patterns and then, propagate at speeds of _30 mm/s. These results demonstrate that under an appropriate visual context, circuitry in visual cortex in alert animals is capable of supporting long-range traveling waves triggered by local stimulation.

KW - Dichoptic stimuli

KW - Traveling wave

KW - Visual cortex

UR - http://www.scopus.com/inward/record.url?scp=84920895656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920895656&partnerID=8YFLogxK

U2 - 10.1152/jn.00610.2013

DO - 10.1152/jn.00610.2013

M3 - Article

C2 - 25343785

AN - SCOPUS:84920895656

VL - 113

SP - 277

EP - 294

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 1

ER -