Long-term follow-up and pattern of failure for T1-T2 glottic cancer after definitive radiation therapy

Waleed Fouad Mourad, Kenneth S. Hu, Rania A. Shourbaji, Rudolph Woode, Louis B. Harrison

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To evaluate the impact of radiation therapy (RT) on the longterm outcomes and pattern of failure for T1-2 glottic cancer. Materials and Methods: This is a single-institution, retrospective study. From January (1997 to 2010), 253 patients with early glottic cancer underwent RT by 2-dimensional or 3-dimensional RT with 60Co or linear accelerator. Appropriate daily bolus was applied with linear accelerator-based RT to avoid under dosage of the anterior commissure. Results: A total of 253 patients with T1-T2 glottic cancer were treated with definitive RT. The median age was 65 and males made up 87% of the population. T1 was 77% of the population. The median dose and fraction size were 63 and 2.25 Gy, respectively. After a median followup of 83 months, the locoregional control (LRC) for the whole cohort was 98%. Specifically, LRCs for T1 (195 patients) and T2 (58 patients) were 99.5% and 91%, respectively. Kaplan-Meier curve shows the 5-year cause-specific survival to be 100%. Conclusions: Single-modality RT provides an excellent and effective treatment for T1-T2 glottic cancer with remarkable functional preservation and 5-year LRC of 98% with negligible long-term toxicity.

Original languageEnglish (US)
Pages (from-to)580-583
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume36
Issue number6
DOIs
StatePublished - Dec 1 2013

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Tongue Neoplasms
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Retrospective Studies
Survival

Keywords

  • Early (T1-T2 true vocal cord) glottic cancer
  • Radiation therapy
  • Squamous cell carcinoma of the larynx

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Long-term follow-up and pattern of failure for T1-T2 glottic cancer after definitive radiation therapy. / Mourad, Waleed Fouad; Hu, Kenneth S.; Shourbaji, Rania A.; Woode, Rudolph; Harrison, Louis B.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 36, No. 6, 01.12.2013, p. 580-583.

Research output: Contribution to journalArticle

Mourad, Waleed Fouad ; Hu, Kenneth S. ; Shourbaji, Rania A. ; Woode, Rudolph ; Harrison, Louis B. / Long-term follow-up and pattern of failure for T1-T2 glottic cancer after definitive radiation therapy. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2013 ; Vol. 36, No. 6. pp. 580-583.
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