@article{69cb5b4ded1d4dfea443b6fd96f01f0f,
title = "Long-term outcomes of children with symptomatic congenital cytomegalovirus disease",
abstract = "Objective: To assess long-term outcomes of children with symptomatic congenital cytomegalovirus (CMV) disease detected at birth. Study Design: We used Cox regression to assess risk factors for intellectual disability (intelligence quotient <70), sensorineural hearing loss (SNHL; hearing level ≥ 25 dB in any audiometric frequency) and vision impairment (best corrected visual acuity >20 or based on ophthalmologist report). Results: Among 76 case-patients followed through median age of 13 (range: 0-27) years, 56 (74%) had SNHL, 31 (43%, n=72) had intellectual disability and 18 (27%, n=66) had vision impairment; 28 (43%, n=65) had intellectual disability and SNHL with/without vision impairment. Microcephaly was significantly associated with each of the three outcomes. Tissue destruction and dysplastic growth on head computed tomography scan at birth was significantly associated with intellectual disability and SNHL. Conclusion: Infants with symptomatic congenital CMV disease may develop moderate to severe impairments that were associated with presence of microcephaly and brain abnormalities.",
author = "{Congenital Cytomegalovirus Longitudinal Study Group} and Lanzieri, {T. M.} and J. Leung and Caviness, {A. C.} and W. Chung and M. Flores and P. Blum and Bialek, {S. R.} and Miller, {J. A.} and Vinson, {S. S.} and Turcich, {M. R.} and Voigt, {R. G.} and G. Demmler-Harrison and Shahzad Ahmed and Hanna Baer and Bhatt, {Amit R.} and Frank Brown and Francis Catlin and Coats, {David K.} and Edmonds, {Jane C.} and Daniel Franklin and Cindy Gandaria and Jewel Greer and Carol Griesser and Hussein, {Mohamed A.} and Isabella Iovino and Allison Istas and Haoxing Jin and Kelinske, {Mary K.} and Klingen, {Joseph T.} and Antone Laurente and Thomas Littman and Mary Murphy and Christopher Nelson and Daniel Noyola and Paysse, {Evelyn A.} and Alan Percy and Sara Reis and Ann Reynolds and Judith Rozelle and O'Brien Smith and Paul Steinkuller and Bethann Walmus and Jill Williams and Daniel Williamson and Yen, {Kimberly G.} and Yow, {Martha D.}",
note = "Funding Information: We thank all the children who participated in the study, their families and physicians for their lifetime of dedication and support for this study, and Kim Van Naarden Braun for careful review of the manuscript. The study was supported, in part, by the CMV Research Fund Donors at Baylor College of Medicine; the Woman's Hospital of Texas Research Foundation; the Office of Research Resources and the General Clinical Research Center for Children at Texas Children's Hospital and Baylor College of Medicine (NIH 5M0I RR00188-33); the Mental Retardation Research Center at Baylor College of Medicine (NIH-CHHD 5 P30 HD24064P); the Research to Prevent Blindness, New York, NY; the Deafness Foundation, Houston, TX; the Vale Ashe Foundation, Houston, TX; the Maddie's Mission Foundation, Katy, TX; the Naymola Foundation, Beaumont, TX; the American Pediatric Society-Society for Pediatric Research Summer Student Research Program (NIH-CHHD); and the Centers for Disease Control and Prevention (Cooperative Agreement FOA IP 10-006).",
year = "2017",
month = jul,
day = "1",
doi = "10.1038/jp.2017.41",
language = "English (US)",
volume = "37",
pages = "875--880",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "7",
}