TY - JOUR
T1 - Long-term outcomes of laparoscopic cholecystectomy
T2 - A prospective piecewise linear regression analysis
AU - Shi, Hon Yi
AU - Lee, Hao Hsien
AU - Tsai, Meng Han
AU - Chiu, Chong Chi
AU - Uen, Yih Huei
AU - Lee, King Teh
PY - 2011/7
Y1 - 2011/7
N2 - Background: The objectives of this study were to examine longitudinal time trends, to predict thresholds of improvement in each dimension of health-related quality of life (HRQoL), and to identify long-term predictors of HRQoL. Methods: This study analyzed 353 laparoscopic cholecystectomy (LC) patients. Disease-specific Gastrointestinal Quality-of-Life Index (GIQLI) and generic Short-Form 36-Item Health Survey (SF-36) scores were obtained immediately before surgery, then 3, 6, 12, and 24 months after surgery. Generalized estimating equations and piecewise linear regression models were used. Results: The examined population significantly (p < 0.05) improved in both SF-36 and GIQLI subscale scores. The HRQoL dimensions were substantially improved the sixth month after surgery and continued improving until they reached a plateau at 54.93 to 73.18 months. The data also showed the following explanatory variables for HRQoL: time, age, gender, Charlson Comorbidity Index, and preoperative GIQLI and SF-36 subscale scores. Conclusions: As shown by the findings, the HRQoL scores improved substantially by the sixth month after surgery and continued improving until they reached a 4- to 7-year threshold, indicating that change trends in HRQoL dimensions may vary. Although HRQoL scores were substantially improved after cholecystectomy, the improvements were associated with preoperative functional status and demographic characteristics.
AB - Background: The objectives of this study were to examine longitudinal time trends, to predict thresholds of improvement in each dimension of health-related quality of life (HRQoL), and to identify long-term predictors of HRQoL. Methods: This study analyzed 353 laparoscopic cholecystectomy (LC) patients. Disease-specific Gastrointestinal Quality-of-Life Index (GIQLI) and generic Short-Form 36-Item Health Survey (SF-36) scores were obtained immediately before surgery, then 3, 6, 12, and 24 months after surgery. Generalized estimating equations and piecewise linear regression models were used. Results: The examined population significantly (p < 0.05) improved in both SF-36 and GIQLI subscale scores. The HRQoL dimensions were substantially improved the sixth month after surgery and continued improving until they reached a plateau at 54.93 to 73.18 months. The data also showed the following explanatory variables for HRQoL: time, age, gender, Charlson Comorbidity Index, and preoperative GIQLI and SF-36 subscale scores. Conclusions: As shown by the findings, the HRQoL scores improved substantially by the sixth month after surgery and continued improving until they reached a 4- to 7-year threshold, indicating that change trends in HRQoL dimensions may vary. Although HRQoL scores were substantially improved after cholecystectomy, the improvements were associated with preoperative functional status and demographic characteristics.
KW - Gastrointestinal Quality-of-Life Index (GIQLI)
KW - Health-related quality of life
KW - Laparoscopic cholecystectomy
KW - Short-Form 36-Item Health Survey (SF-36)
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U2 - 10.1007/s00464-010-1508-x
DO - 10.1007/s00464-010-1508-x
M3 - Article
AN - SCOPUS:79960432155
SN - 0930-2794
VL - 25
SP - 2132
EP - 2140
JO - Surgical endoscopy
JF - Surgical endoscopy
IS - 7
ER -