Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine

William Almaguer-Melian, Yeneissy Rojas-Reyes, Armando Alvare, Juan C. Rosillo, Julietta Uta Frey, Jorge A. Bergado

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Growing evidence suggests that processes of synaptic plasticity, such as long-term potentiation (LTP) occurring in one synaptic population, can be modulated by consolidating afferents from other brain structures. We have previously shown that an early-LTP lasting less than 4 h (E-LTP) in the dentate gyrus can be prolonged by stimulating the basolateral amygdala, the septum or the locus coeruleus within a specific time window. Pharmacological experiments have suggested that noradregeneric (NE) and/or cholinergic systems might be involved in these effects. We have therefore investigated whether the direct intraventricular application of agonists for NE- or muscarinic receptors is able to modulate synaptic plasticity. E-LTP was induced at the dentate gyrus of freely moving rats using a mild tetanization protocol that induces only an E-LTP. NE or oxotremorine (OXO) were applied icv 10 min after the tetanus. Results show that low doses of NE (1.5 and 5 nM) effectively prolong LTP. A higher dose (50 nM) was not effective. None of the OXO doses employed (5, 25, and 50 nM) showed similar effects. These results stress the importance of transmitter-specific modulatory influences on the time course of synaptic plasticity, in particular NE whose application mimics the reinforcing effect of directly stimulating limbic structures on LTP.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalNeurobiology of Learning and Memory
Volume83
Issue number1
DOIs
StatePublished - Jan 1 2005

Fingerprint

Oxotremorine
Long-Term Potentiation
Dentate Gyrus
Norepinephrine
Neuronal Plasticity
Locus Coeruleus
Tetanus
Muscarinic Receptors
Cholinergic Agents
Pharmacology
Brain

Keywords

  • Early-LTP
  • Functional plasticity
  • Late-LTP
  • Long-term potentiation
  • Norepinephrine
  • Oxotremorine
  • Reinforcement

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine. / Almaguer-Melian, William; Rojas-Reyes, Yeneissy; Alvare, Armando; Rosillo, Juan C.; Frey, Julietta Uta; Bergado, Jorge A.

In: Neurobiology of Learning and Memory, Vol. 83, No. 1, 01.01.2005, p. 72-78.

Research output: Contribution to journalArticle

Almaguer-Melian, William ; Rojas-Reyes, Yeneissy ; Alvare, Armando ; Rosillo, Juan C. ; Frey, Julietta Uta ; Bergado, Jorge A. / Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine. In: Neurobiology of Learning and Memory. 2005 ; Vol. 83, No. 1. pp. 72-78.
@article{f6e305604e764d80b7fe72ad375e63c2,
title = "Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine",
abstract = "Growing evidence suggests that processes of synaptic plasticity, such as long-term potentiation (LTP) occurring in one synaptic population, can be modulated by consolidating afferents from other brain structures. We have previously shown that an early-LTP lasting less than 4 h (E-LTP) in the dentate gyrus can be prolonged by stimulating the basolateral amygdala, the septum or the locus coeruleus within a specific time window. Pharmacological experiments have suggested that noradregeneric (NE) and/or cholinergic systems might be involved in these effects. We have therefore investigated whether the direct intraventricular application of agonists for NE- or muscarinic receptors is able to modulate synaptic plasticity. E-LTP was induced at the dentate gyrus of freely moving rats using a mild tetanization protocol that induces only an E-LTP. NE or oxotremorine (OXO) were applied icv 10 min after the tetanus. Results show that low doses of NE (1.5 and 5 nM) effectively prolong LTP. A higher dose (50 nM) was not effective. None of the OXO doses employed (5, 25, and 50 nM) showed similar effects. These results stress the importance of transmitter-specific modulatory influences on the time course of synaptic plasticity, in particular NE whose application mimics the reinforcing effect of directly stimulating limbic structures on LTP.",
keywords = "Early-LTP, Functional plasticity, Late-LTP, Long-term potentiation, Norepinephrine, Oxotremorine, Reinforcement",
author = "William Almaguer-Melian and Yeneissy Rojas-Reyes and Armando Alvare and Rosillo, {Juan C.} and Frey, {Julietta Uta} and Bergado, {Jorge A.}",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/j.nlm.2004.08.002",
language = "English (US)",
volume = "83",
pages = "72--78",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine

AU - Almaguer-Melian, William

AU - Rojas-Reyes, Yeneissy

AU - Alvare, Armando

AU - Rosillo, Juan C.

AU - Frey, Julietta Uta

AU - Bergado, Jorge A.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Growing evidence suggests that processes of synaptic plasticity, such as long-term potentiation (LTP) occurring in one synaptic population, can be modulated by consolidating afferents from other brain structures. We have previously shown that an early-LTP lasting less than 4 h (E-LTP) in the dentate gyrus can be prolonged by stimulating the basolateral amygdala, the septum or the locus coeruleus within a specific time window. Pharmacological experiments have suggested that noradregeneric (NE) and/or cholinergic systems might be involved in these effects. We have therefore investigated whether the direct intraventricular application of agonists for NE- or muscarinic receptors is able to modulate synaptic plasticity. E-LTP was induced at the dentate gyrus of freely moving rats using a mild tetanization protocol that induces only an E-LTP. NE or oxotremorine (OXO) were applied icv 10 min after the tetanus. Results show that low doses of NE (1.5 and 5 nM) effectively prolong LTP. A higher dose (50 nM) was not effective. None of the OXO doses employed (5, 25, and 50 nM) showed similar effects. These results stress the importance of transmitter-specific modulatory influences on the time course of synaptic plasticity, in particular NE whose application mimics the reinforcing effect of directly stimulating limbic structures on LTP.

AB - Growing evidence suggests that processes of synaptic plasticity, such as long-term potentiation (LTP) occurring in one synaptic population, can be modulated by consolidating afferents from other brain structures. We have previously shown that an early-LTP lasting less than 4 h (E-LTP) in the dentate gyrus can be prolonged by stimulating the basolateral amygdala, the septum or the locus coeruleus within a specific time window. Pharmacological experiments have suggested that noradregeneric (NE) and/or cholinergic systems might be involved in these effects. We have therefore investigated whether the direct intraventricular application of agonists for NE- or muscarinic receptors is able to modulate synaptic plasticity. E-LTP was induced at the dentate gyrus of freely moving rats using a mild tetanization protocol that induces only an E-LTP. NE or oxotremorine (OXO) were applied icv 10 min after the tetanus. Results show that low doses of NE (1.5 and 5 nM) effectively prolong LTP. A higher dose (50 nM) was not effective. None of the OXO doses employed (5, 25, and 50 nM) showed similar effects. These results stress the importance of transmitter-specific modulatory influences on the time course of synaptic plasticity, in particular NE whose application mimics the reinforcing effect of directly stimulating limbic structures on LTP.

KW - Early-LTP

KW - Functional plasticity

KW - Late-LTP

KW - Long-term potentiation

KW - Norepinephrine

KW - Oxotremorine

KW - Reinforcement

UR - http://www.scopus.com/inward/record.url?scp=10944220456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10944220456&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2004.08.002

DO - 10.1016/j.nlm.2004.08.002

M3 - Article

C2 - 15607691

AN - SCOPUS:10944220456

VL - 83

SP - 72

EP - 78

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -