Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

Uwe Frey, Manfred Krug, Rudolf Brödemann, Klaus Reymann, Hansjürgen Matthies

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalNeuroscience Letters
Volume97
Issue number1-2
DOIs
StatePublished - Feb 13 1989

Keywords

  • Field potential
  • Hippocampal CA1
  • Isolated dendrite
  • Long-term potentiation
  • Slice preparation

ASJC Scopus subject areas

  • Neuroscience(all)

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