Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

Uwe Frey; Manfred Krug; Rudolf Brödemann; Klaus Reymann; Hansjürgen Matthies

doi:10.1016/0304-3940(89)90152-3

Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

Uwe Frey, Manfred Krug, Rudolf Brödemann, Klaus Reymann, Hansjürgen Matthies

Neurology

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90 Scopus citations

Abstract

In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.

Original language	English (US)
Pages (from-to)	135-139
Number of pages	5
Journal	Neuroscience Letters
Volume	97
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(89)90152-3
State	Published - Feb 13 1989

Keywords

Field potential
Hippocampal CA1
Isolated dendrite
Long-term potentiation
Slice preparation

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(89)90152-3

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abstract = "In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.",

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T1 - Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

AU - Frey, Uwe

AU - Krug, Manfred

AU - Brödemann, Rudolf

AU - Reymann, Klaus

AU - Matthies, Hansjürgen

PY - 1989/2/13

Y1 - 1989/2/13

N2 - In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.

AB - In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.

KW - Field potential

KW - Hippocampal CA1

KW - Isolated dendrite

KW - Long-term potentiation

KW - Slice preparation

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Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

Abstract

Keywords

ASJC Scopus subject areas

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