Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

Julietta Uta Frey, Manfred Krug, Rudolf Brödemann, Klaus Reymann, Hansjürgen Matthies

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

In 14 transversal hippocampal slices from rats the extracellular field-EPSP (excitatory postsynaptic potential) in the dendritic region of the CA1 subfield was recorded after isolating the apical dendrites from their somata by microsurgical cuts through the proximal stratum radiatum. Contrary to intact slices which, after tetanic stimulation of the Schaffer collaterals, showed long-term potentiation (LTP) until the end of registration after 8-10 h, LTP declined in the isolated dendrites to baseline values after 3 h. It is concluded that de-novo protein synthesis in postsynaptic cell bodies might be necessary for the maintenance of late phases of LTP.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalNeuroscience Letters
Volume97
Issue number1-2
DOIs
StatePublished - Feb 13 1989

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Long-Term Potentiation
Carisoprodol
Dendrites
Excitatory Postsynaptic Potentials
Hippocampus
Maintenance
Proteins

Keywords

  • Field potential
  • Hippocampal CA1
  • Isolated dendrite
  • Long-term potentiation
  • Slice preparation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase. / Frey, Julietta Uta; Krug, Manfred; Brödemann, Rudolf; Reymann, Klaus; Matthies, Hansjürgen.

In: Neuroscience Letters, Vol. 97, No. 1-2, 13.02.1989, p. 135-139.

Research output: Contribution to journalArticle

Frey, Julietta Uta ; Krug, Manfred ; Brödemann, Rudolf ; Reymann, Klaus ; Matthies, Hansjürgen. / Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase. In: Neuroscience Letters. 1989 ; Vol. 97, No. 1-2. pp. 135-139.
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