Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler

R. J. Adams, V. C. McKie, E. M. Carl, F. T. Nichols, R. Perry, K. Brock, K. McKie, R. Figueroa, M. Litaker, S. Weiner, D. Brambilla

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Abstract

Stroke is an important complication of sickle cell disease. Stroke prediction is clinically important because it offers the possibility of primary prevention. In 1992, transcranial Doppler (TCD) evidence of elevated intracranial internal carotid or middle cerebral artery velocity was demonstrated to be associated strongly with an increased risk of ischemic stroke. This study extends the original study and includes 125 more children, longer follow-up, and intracranial hemorrhage in the stroke-risk model. Elevated time averaged mean maximum blood flow velocity, especially when velocity is 200 cm/sec or greater by TCD, was associated strongly with stroke risk. The cases not predicted by TCD point to the need for more information on the optimal timing of TCD surveillance for stroke risk.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalAnnals of Neurology
Volume42
Issue number5
DOIs
StatePublished - Nov 1 1997

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Adams, R. J., McKie, V. C., Carl, E. M., Nichols, F. T., Perry, R., Brock, K., McKie, K., Figueroa, R., Litaker, M., Weiner, S., & Brambilla, D. (1997). Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler. Annals of Neurology, 42(5), 699-704. https://doi.org/10.1002/ana.410420505