Longitudinal cognitive performance in older adults with cardiovascular disease

Evidence for improvement in Heart Failure

Kelly M Stanek, John Gunstad, Robert H. Paul, Athena Poppas, Angela L. Jefferson, Lawrence H. Sweet, Karin F. Hoth, Andreana P. Haley, Daniel E. Forman, Ronald A. Cohen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND:: Cardiovascular disease (CVD) and particularly heart failure (HF) have been associated with cognitive impairment in cross-sectional studies, but it is unclear how cognitive impairment progresses over time in older adults with these conditions. OBJECTIVE:: The aim of this study was to prospectively examine cognitive function in patients with HF versus other forms of CVD. METHOD:: Seventy-five older adults (aged 53-84 years) with CVD underwent Doppler echocardiogram to evaluate cardiac status and 2 administrations of the Dementia Rating Scale (DRS), a test of global cognitive functioning, 12 months apart. RESULTS:: Although DRS performance did not statistically differ between groups at either administration, a significant between-group difference in the rate of cognitive change emerged (λ = 0.87; F = 10.50; P = .002; ω = 0.11). Follow-up analyses revealed that patients with HF improved significantly on global DRS performance, whereas patients with other forms of CVD remained stable. More specifically, patients with HF showed improvement on subscales of attention, initiation/perseveration, and conceptualization. Exploratory analyses indicated that higher diastolic blood pressure at baseline was associated with improved DRS performance in patients with HF (r = 0.38; P = .02). CONCLUSIONS:: Patients with HF exhibited modest cognitive improvements during 12 months, particularly in attention and executive functioning. Higher diastolic blood pressure at baseline was associated with improvement. These results suggest that cognitive impairment in patients with HF may be modifiable and that improved blood pressure control may be an important contributor to improved function. Further prospective studies are needed to replicate results and determine underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
JournalJournal of Cardiovascular Nursing
Volume24
Issue number3
DOIs
StatePublished - May 1 2009

Fingerprint

Cardiovascular Diseases
Heart Failure
Dementia
Blood Pressure
Hypertension
Cognition
Cross-Sectional Studies
Prospective Studies
Cognitive Dysfunction

Keywords

  • Cardiovascular disease
  • Cognitive impairment
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Longitudinal cognitive performance in older adults with cardiovascular disease : Evidence for improvement in Heart Failure. / Stanek, Kelly M; Gunstad, John; Paul, Robert H.; Poppas, Athena; Jefferson, Angela L.; Sweet, Lawrence H.; Hoth, Karin F.; Haley, Andreana P.; Forman, Daniel E.; Cohen, Ronald A.

In: Journal of Cardiovascular Nursing, Vol. 24, No. 3, 01.05.2009, p. 192-197.

Research output: Contribution to journalArticle

Stanek, KM, Gunstad, J, Paul, RH, Poppas, A, Jefferson, AL, Sweet, LH, Hoth, KF, Haley, AP, Forman, DE & Cohen, RA 2009, 'Longitudinal cognitive performance in older adults with cardiovascular disease: Evidence for improvement in Heart Failure', Journal of Cardiovascular Nursing, vol. 24, no. 3, pp. 192-197. https://doi.org/10.1097/JCN.0b013e31819b54de
Stanek, Kelly M ; Gunstad, John ; Paul, Robert H. ; Poppas, Athena ; Jefferson, Angela L. ; Sweet, Lawrence H. ; Hoth, Karin F. ; Haley, Andreana P. ; Forman, Daniel E. ; Cohen, Ronald A. / Longitudinal cognitive performance in older adults with cardiovascular disease : Evidence for improvement in Heart Failure. In: Journal of Cardiovascular Nursing. 2009 ; Vol. 24, No. 3. pp. 192-197.
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