"Look-ahead distance" of a fiber probe used to assist neurosurgery: Phantom and Monte Carlo study

Zhiyu Qian, Sunder S. Victor, Yueqing Gu, Cole A. Giller, Hanli Liu

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A short-separation, optical reflectance probe has been developed to assist the neurosurgeon in functional neurosurgery for accurate localization of the surgical target. Because of the scattering nature of tissue, the optical probe has a "Look Ahead Distance" (LAD), at which the measured optical reflectance starts to "see" or "sense" the underlying brain structure due to the difference in light scattering of tissue. To quantify the LAD, 2-layer laboratory phantoms have been developed to mimic gray and white matter of the brain, and Monte Carlo simulations have been also used to confirm the experimental findings. Based on both the laboratory and simulation results, a quantitative empirical equation is developed to express the LAD as a function of scattering coefficient of the measured tissue for a 400-micron-diameter fiber probe. The quantified LAD of the probe is highly desirable so as to improve the spatial resolution of the probe for better surgery guidance.

Original languageEnglish (US)
Pages (from-to)1844-1855
Number of pages12
JournalOptics Express
Volume11
Issue number16
DOIs
StatePublished - Aug 2003

Fingerprint

fibers
probes
brain
reflectance
scattering coefficients
surgery
light scattering
simulation
spatial resolution
scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

"Look-ahead distance" of a fiber probe used to assist neurosurgery : Phantom and Monte Carlo study. / Qian, Zhiyu; Victor, Sunder S.; Gu, Yueqing; Giller, Cole A.; Liu, Hanli.

In: Optics Express, Vol. 11, No. 16, 08.2003, p. 1844-1855.

Research output: Contribution to journalArticle

Qian, Zhiyu ; Victor, Sunder S. ; Gu, Yueqing ; Giller, Cole A. ; Liu, Hanli. / "Look-ahead distance" of a fiber probe used to assist neurosurgery : Phantom and Monte Carlo study. In: Optics Express. 2003 ; Vol. 11, No. 16. pp. 1844-1855.
@article{2a4e8cc834074651ba7759960ec1d37e,
title = "{"}Look-ahead distance{"} of a fiber probe used to assist neurosurgery: Phantom and Monte Carlo study",
abstract = "A short-separation, optical reflectance probe has been developed to assist the neurosurgeon in functional neurosurgery for accurate localization of the surgical target. Because of the scattering nature of tissue, the optical probe has a {"}Look Ahead Distance{"} (LAD), at which the measured optical reflectance starts to {"}see{"} or {"}sense{"} the underlying brain structure due to the difference in light scattering of tissue. To quantify the LAD, 2-layer laboratory phantoms have been developed to mimic gray and white matter of the brain, and Monte Carlo simulations have been also used to confirm the experimental findings. Based on both the laboratory and simulation results, a quantitative empirical equation is developed to express the LAD as a function of scattering coefficient of the measured tissue for a 400-micron-diameter fiber probe. The quantified LAD of the probe is highly desirable so as to improve the spatial resolution of the probe for better surgery guidance.",
author = "Zhiyu Qian and Victor, {Sunder S.} and Yueqing Gu and Giller, {Cole A.} and Hanli Liu",
year = "2003",
month = "8",
doi = "10.1364/OE.11.001844",
language = "English (US)",
volume = "11",
pages = "1844--1855",
journal = "Optics Express",
issn = "1094-4087",
publisher = "The Optical Society",
number = "16",

}

TY - JOUR

T1 - "Look-ahead distance" of a fiber probe used to assist neurosurgery

T2 - Phantom and Monte Carlo study

AU - Qian, Zhiyu

AU - Victor, Sunder S.

AU - Gu, Yueqing

AU - Giller, Cole A.

AU - Liu, Hanli

PY - 2003/8

Y1 - 2003/8

N2 - A short-separation, optical reflectance probe has been developed to assist the neurosurgeon in functional neurosurgery for accurate localization of the surgical target. Because of the scattering nature of tissue, the optical probe has a "Look Ahead Distance" (LAD), at which the measured optical reflectance starts to "see" or "sense" the underlying brain structure due to the difference in light scattering of tissue. To quantify the LAD, 2-layer laboratory phantoms have been developed to mimic gray and white matter of the brain, and Monte Carlo simulations have been also used to confirm the experimental findings. Based on both the laboratory and simulation results, a quantitative empirical equation is developed to express the LAD as a function of scattering coefficient of the measured tissue for a 400-micron-diameter fiber probe. The quantified LAD of the probe is highly desirable so as to improve the spatial resolution of the probe for better surgery guidance.

AB - A short-separation, optical reflectance probe has been developed to assist the neurosurgeon in functional neurosurgery for accurate localization of the surgical target. Because of the scattering nature of tissue, the optical probe has a "Look Ahead Distance" (LAD), at which the measured optical reflectance starts to "see" or "sense" the underlying brain structure due to the difference in light scattering of tissue. To quantify the LAD, 2-layer laboratory phantoms have been developed to mimic gray and white matter of the brain, and Monte Carlo simulations have been also used to confirm the experimental findings. Based on both the laboratory and simulation results, a quantitative empirical equation is developed to express the LAD as a function of scattering coefficient of the measured tissue for a 400-micron-diameter fiber probe. The quantified LAD of the probe is highly desirable so as to improve the spatial resolution of the probe for better surgery guidance.

UR - http://www.scopus.com/inward/record.url?scp=2942715012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942715012&partnerID=8YFLogxK

U2 - 10.1364/OE.11.001844

DO - 10.1364/OE.11.001844

M3 - Article

C2 - 19466067

AN - SCOPUS:2942715012

VL - 11

SP - 1844

EP - 1855

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 16

ER -