Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais

Lishomwa C. Ndhlovu; Michelle L. D'Antoni; Jintanat Ananworanich; Mary Margaret Byron; Thep Chalermchai; Pasiri Sithinamsuwan; Somporn Tipsuk; Erika Ho; Bonnie M. Slike; Alexandra Schuetz; Guangxiang Zhang; Melissa Agsalda-Garcia; Bruce Shiramizu; Cecilia M. Shikuma; Victor Valcour

doi:10.1016/j.jneuroim.2015.08.020

Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais

Lishomwa C. Ndhlovu, Michelle L. D'Antoni, Jintanat Ananworanich, Mary Margaret Byron, Thep Chalermchai, Pasiri Sithinamsuwan, Somporn Tipsuk, Erika Ho, Bonnie M. Slike, Alexandra Schuetz, Guangxiang Zhang, Melissa Agsalda-Garcia, Bruce Shiramizu, Cecilia M. Shikuma, Victor Valcour

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2⁺non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2⁺non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2⁺non-classical monocytes as an independent index of cognitive impairment.

Original language	English (US)
Pages (from-to)	25-33
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	288
DOIs	https://doi.org/10.1016/j.jneuroim.2015.08.020
State	Published - Nov 15 2015
Externally published	Yes

Keywords

C-C chemokine receptor (CCR) CCR2
CD163
HIV-associated neurocognitive disorders (HAND)
Monocytes
Neopterin

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jneuroim.2015.08.020

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Ndhlovu, L. C., D'Antoni, M. L., Ananworanich, J., Byron, M. M., Chalermchai, T., Sithinamsuwan, P., Tipsuk, S., Ho, E., Slike, B. M., Schuetz, A., Zhang, G., Agsalda-Garcia, M., Shiramizu, B., Shikuma, C. M., & Valcour, V. (2015). Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais. Journal of Neuroimmunology, 288, 25-33. https://doi.org/10.1016/j.jneuroim.2015.08.020

Ndhlovu, LC, D'Antoni, ML, Ananworanich, J, Byron, MM, Chalermchai, T, Sithinamsuwan, P, Tipsuk, S, Ho, E, Slike, BM, Schuetz, A, Zhang, G, Agsalda-Garcia, M, Shiramizu, B, Shikuma, CM & Valcour, V 2015, 'Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais', Journal of Neuroimmunology, vol. 288, pp. 25-33. https://doi.org/10.1016/j.jneuroim.2015.08.020

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abstract = "HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-na{\"i}ve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.",

keywords = "C-C chemokine receptor (CCR) CCR2, CD163, HIV-associated neurocognitive disorders (HAND), Monocytes, Neopterin",

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doi = "10.1016/j.jneuroim.2015.08.020",

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AU - Ndhlovu, Lishomwa C.

AU - D'Antoni, Michelle L.

AU - Ananworanich, Jintanat

AU - Byron, Mary Margaret

AU - Chalermchai, Thep

AU - Sithinamsuwan, Pasiri

AU - Tipsuk, Somporn

AU - Ho, Erika

AU - Slike, Bonnie M.

AU - Schuetz, Alexandra

AU - Zhang, Guangxiang

AU - Agsalda-Garcia, Melissa

AU - Shiramizu, Bruce

AU - Shikuma, Cecilia M.

AU - Valcour, Victor

PY - 2015/11/15

Y1 - 2015/11/15

N2 - HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.

AB - HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.

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KW - CD163

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KW - Neopterin

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ER -

Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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