Loss-of-function PTPRD mutations lead to increased STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

Medicine & Life Sciences

• Class 2 Receptor-Like Protein Tyrosine Phosphatases 100%
• Head and Neck Neoplasms 58%
• Squamous Cell Carcinoma of Head and Neck 47%
• Mutation 32%
• Methylation 9%
• tyrosine receptor 7%
• Protein Tyrosine Phosphatases 6%
• STAT3 Transcription Factor 6%
• Gene Dosage 6%
• Whole Exome Sequencing 6%
• Messenger RNA 6%
• Atlases 5%
• Neoplasms 5%
• Oncogenes 5%
• Epigenomics 4%
• Transfection 4%
• Phosphorylation 3%
• Genome 3%
• Polymerase Chain Reaction 3%
• Growth 2%
• In Vitro Techniques 2%