Low 25-hydroxyvitamin D levels in adolescents: Race, season, adiposity, physical activity, and fitness

Yanbin Dong, Norman K. Pollock, Inger Susanne Stallmann-Jorgensen, Bernard Gutin, Ling Lan, Tai C. Chen, Daniel Keeton, Karen Petty, Michael F. Holick, Haidong Zhu

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

OBJECTIVES: The objectives were to characterize the vitamin D status of black and white adolescents residing in the southeastern United States (latitude: ∼33°N) and to investigate relationships with adiposity. METHODS: Plasma 25-hydroxyvitamin D levels were measured with liquid chromatography-tandem mass spectroscopy for 559 adolescents 14 to 18 years of age (45% black and 49% female). Fat tissues, physical activity, and cardiovascular fitness also were measured. RESULTS: The overall prevalences of vitamin D insufficiency (<75 nmol/L) and deficiency (≥50 nmol/L) were 56.4% and 28.8%, respectively. Black versus white subjects had significantly lower plasma 25-hydroxyvitamin D levels in every season (winter, 35.9 ± 2.5 vs 77.4 ± 2.7 nmol/L; spring, 46.4±3.5 vs 101.3±3.5 nmol/L; summer, 50.7±4.0 vs 104.3 ± 4.0 nmol/L; autumn, 54.4 ± 4.0 vs 96.8 ± 2.7 nmol/L). With adjustment for age, gender, race, season, height, and sexual maturation, there were significant inverse correlations between 25-hydroxyvitamin D levels and all adiposity measurements, including BMI percentile (P=.02), waist circumference (P<.01), total fat mass (P< .01), percentage of body fat (P < .01), visceral adipose tissue (P = .015), and subcutaneous abdominal adipose tissue (P < .039). There were significant positive associations between 25-hydroxyvitamin D levels and vigorous physical activity (P < .01) and cardiovascular fitness (P = .025). CONCLUSIONS: Low vitamin D status is prevalent among adolescents living in a year-round sunny climate, particularly among black youths. The relationships between 25-hydroxyvitamin D levels, adiposity, physical activity, and fitness seem to be present in adolescence.

Original languageEnglish (US)
Pages (from-to)1104-1111
Number of pages8
JournalPediatrics
Volume125
Issue number6
DOIs
StatePublished - Jun 1 2010

Keywords

  • 25-hydroxyvitamin D
  • Adiposity
  • Adolescents
  • Fitness
  • Physical activity
  • Race
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Dong, Y., Pollock, N. K., Stallmann-Jorgensen, I. S., Gutin, B., Lan, L., Chen, T. C., Keeton, D., Petty, K., Holick, M. F., & Zhu, H. (2010). Low 25-hydroxyvitamin D levels in adolescents: Race, season, adiposity, physical activity, and fitness. Pediatrics, 125(6), 1104-1111. https://doi.org/10.1542/peds.2009-2055