Low dose interleukin-11 is well-tolerated and induces platelet responses in myelodysplasia and other bone marrow failure states

R. Kurzrock, J. Cortes, D. Thomas, S. Pilât, M. Talpaz

Research output: Contribution to journalArticle

Abstract

Interleukin-11 (IL-11) is a thrombopoietic cytokine that attenuates post-chemotherapy thrombocytopenia. The dose used post-chemotherapy is = 50 ng/kg/day s.c. Very little is known about the activity of IL-11 in bone marrow failure states. Our preliminary experience with IL-11 at doses of 50 ng/kg/day suggested that bone marrow failure patients developed significant peripheral and pulmonary edema after the prolonged dosing necessary for treating these conditions. We therefore initiated a study of low-dose IL-11 (10 jig/kg/d). Response criteria included doubling of platelets and rise to 50 x lO'/L or tripling of platelets and rise to 20 × 109/L. Sixteen pts are évaluable for response. Their median age was 58 years (range, 5 to 84 years). Six pts had diploid cytogenetics; the others had a variety of chromosomal abnormalities. Six of 16 pts (38%) showed a platelet response to IL-11 and two had a multilineage response (to IL-11 alone (N=l); to IL-11 + G-CSFand EPO (N=l)). Responders included 5 of 11 pts with myelodysplasia (MDS) and 1 of 4 patients with aplastic anemia (AA). Response duration was 12, 13, 14+, 22+, 25 and 30 weeks. Side-effects of IL-11 were mild (peripheral edema, N=7; conjunctival injection, N=7 or myalgia (N=l) (all grade 1). Seven pts had no side-effects. Our pilot study suggests that administration of low dose IL-11 (10μg/kg/day) can raise platelet counts, without significant toxicity, in selected thrombocytopenic patients with bone marrow failure.

Original languageEnglish (US)
Pages (from-to)147a
JournalBlood
Volume96
Issue number11 PART I
StatePublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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