Low rates of contralateral neck failure in unilaterally treated oropharyngeal squamous cell carcinoma with prospectively defined criteria of lateralization

Kenneth Shung Hu, Waleed Fouad Mourad, Mauricio Gamez, Joseph Safdieh, Wilson Lin, Adam Saul Jacobson, Mark Stephen Persky, Mark Lawrence Urken, Bruce Culliney, Zujun Li, Theresa Nguyen Tran, Stimson Pryor Schantz, Juskaran Chadha, Louis Benjamin Harrison

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Unilateral radiotherapy (RT) of oropharyngeal carcinomas is accepted for patients with lateralized primary and low-volume nodal disease. Utilizing prospectively defined criteria of laterality and staging positron emission tomography (PET)/CT, we studied outcomes in patients with advanced-stage oropharyngeal cancer undergoing unilateral RT. Methods: Thirty-seven patients with oropharyngeal tumors >1 cm from midline regardless of node status underwent unilateral RT and were followed prospectively. Patient characteristics: T1 = 11; T2 = 22; T3 = 4; N0 = 3; N1 = 9; N2a = 3; N2b = 21; and Nx = 1. Dosimetry were determined and weekly National Comprehensive Cancer Network (NCCN) distress thermometer data were collected. Results: At median follow-up of 32 months, 3-year locoregional control, contralateral regional failure, distant metastasis-free survival, and disease-free survival were 96%, 0%, 7%, and 93%, respectively. Conclusion: Low rates of contralateral neck failure are demonstrated utilizing prospectively defined criteria for unilateral RT. The tolerances of contralateral organs are respected and patients report low to moderate levels of distress throughout treatment.

Original languageEnglish (US)
Pages (from-to)1647-1654
Number of pages8
JournalHead and Neck
Volume39
Issue number8
DOIs
StatePublished - Aug 1 2017

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Squamous Cell Carcinoma
Neck
Radiotherapy
Oropharyngeal Neoplasms
Thermometers
Positron-Emission Tomography
Disease-Free Survival
Neoplasms
Neoplasm Metastasis
Carcinoma
Therapeutics

Keywords

  • human papillomavirus (HPV)
  • radiotherapy
  • tonsil
  • toxicity
  • unilateral

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Low rates of contralateral neck failure in unilaterally treated oropharyngeal squamous cell carcinoma with prospectively defined criteria of lateralization. / Hu, Kenneth Shung; Mourad, Waleed Fouad; Gamez, Mauricio; Safdieh, Joseph; Lin, Wilson; Jacobson, Adam Saul; Persky, Mark Stephen; Urken, Mark Lawrence; Culliney, Bruce; Li, Zujun; Tran, Theresa Nguyen; Schantz, Stimson Pryor; Chadha, Juskaran; Harrison, Louis Benjamin.

In: Head and Neck, Vol. 39, No. 8, 01.08.2017, p. 1647-1654.

Research output: Contribution to journalArticle

Hu, KS, Mourad, WF, Gamez, M, Safdieh, J, Lin, W, Jacobson, AS, Persky, MS, Urken, ML, Culliney, B, Li, Z, Tran, TN, Schantz, SP, Chadha, J & Harrison, LB 2017, 'Low rates of contralateral neck failure in unilaterally treated oropharyngeal squamous cell carcinoma with prospectively defined criteria of lateralization', Head and Neck, vol. 39, no. 8, pp. 1647-1654. https://doi.org/10.1002/hed.24806
Hu, Kenneth Shung ; Mourad, Waleed Fouad ; Gamez, Mauricio ; Safdieh, Joseph ; Lin, Wilson ; Jacobson, Adam Saul ; Persky, Mark Stephen ; Urken, Mark Lawrence ; Culliney, Bruce ; Li, Zujun ; Tran, Theresa Nguyen ; Schantz, Stimson Pryor ; Chadha, Juskaran ; Harrison, Louis Benjamin. / Low rates of contralateral neck failure in unilaterally treated oropharyngeal squamous cell carcinoma with prospectively defined criteria of lateralization. In: Head and Neck. 2017 ; Vol. 39, No. 8. pp. 1647-1654.
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AU - Mourad, Waleed Fouad

AU - Gamez, Mauricio

AU - Safdieh, Joseph

AU - Lin, Wilson

AU - Jacobson, Adam Saul

AU - Persky, Mark Stephen

AU - Urken, Mark Lawrence

AU - Culliney, Bruce

AU - Li, Zujun

AU - Tran, Theresa Nguyen

AU - Schantz, Stimson Pryor

AU - Chadha, Juskaran

AU - Harrison, Louis Benjamin

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AB - Background: Unilateral radiotherapy (RT) of oropharyngeal carcinomas is accepted for patients with lateralized primary and low-volume nodal disease. Utilizing prospectively defined criteria of laterality and staging positron emission tomography (PET)/CT, we studied outcomes in patients with advanced-stage oropharyngeal cancer undergoing unilateral RT. Methods: Thirty-seven patients with oropharyngeal tumors >1 cm from midline regardless of node status underwent unilateral RT and were followed prospectively. Patient characteristics: T1 = 11; T2 = 22; T3 = 4; N0 = 3; N1 = 9; N2a = 3; N2b = 21; and Nx = 1. Dosimetry were determined and weekly National Comprehensive Cancer Network (NCCN) distress thermometer data were collected. Results: At median follow-up of 32 months, 3-year locoregional control, contralateral regional failure, distant metastasis-free survival, and disease-free survival were 96%, 0%, 7%, and 93%, respectively. Conclusion: Low rates of contralateral neck failure are demonstrated utilizing prospectively defined criteria for unilateral RT. The tolerances of contralateral organs are respected and patients report low to moderate levels of distress throughout treatment.

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