Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: A meta-prediction of worldwide populations

Pojui Yu, Joyce D. Kusuma, Maria Aurora R. Suarez, Shyang Yun Pamela Koong Shiao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glutathione S transferase mu 1 (GSTM1) gene has been associated with lung cancer (LC) risk, for GSTM1 enzyme playing a vital role in detoxification pathway and protective against toxic insults. The major objective of this study was to investigate GSTM1 deletion pattern and its association with LC in the world's population by using meta-prediction techniques. The secondary objective was to examine the effects of air pollution, smoking status, and other factors for gene-environment interactions with GSTM1 deletion and LC risk. We completed a comprehensive search to yield a total of 170 studies (40,296 cases and 48,346 controls) published from 1999 to 2017 for metaanalyses. The results revealed that GSTM1 deletion type was associated with increased risk of LC, while GSTM1 present type provided protective effect for all populations combined worldwide. Subgroup analysis on the rank order of risks from highest to lowest, among racial-ethnic groups, were Chinese, South East Asian, other North Asian, European, and finally American. Additional predictive analyses presented that air pollution played a significant role with increased risks of GSTM1 deletion and LC susceptibility, and the risks increased for smokers with higher levels of air pollution. Based on the findings of meta-predictive analysis, increased air pollution levels and smoking status presented additive effects to the LC risk susceptibilities and GSTM1 gene polymorphisms, for gene-environment interactions. Future studies are needed to examine gene-environment interactions for GSTM1 interacting with environmental factors and dietary interventions to mitigate the toxic effects, for LC prevention.

Original languageEnglish (US)
Pages (from-to)31120-31132
Number of pages13
JournalOncotarget
Volume9
Issue number57
DOIs
StatePublished - Jul 24 2018

Fingerprint

Air Pollution
Glutathione Transferase
Lung Neoplasms
Smoking
Population
Gene-Environment Interaction
Poisons

Keywords

  • Air pollution
  • Glutathione S transferase mu 1
  • Lung cancer
  • Meta-prediction
  • Smoking

ASJC Scopus subject areas

  • Oncology

Cite this

Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status : A meta-prediction of worldwide populations. / Yu, Pojui; Kusuma, Joyce D.; Suarez, Maria Aurora R.; Shiao, Shyang Yun Pamela Koong.

In: Oncotarget, Vol. 9, No. 57, 24.07.2018, p. 31120-31132.

Research output: Contribution to journalArticle

Yu, Pojui ; Kusuma, Joyce D. ; Suarez, Maria Aurora R. ; Shiao, Shyang Yun Pamela Koong. / Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status : A meta-prediction of worldwide populations. In: Oncotarget. 2018 ; Vol. 9, No. 57. pp. 31120-31132.
@article{9c8a402d41204f2790de3a816f11478d,
title = "Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: A meta-prediction of worldwide populations",
abstract = "Glutathione S transferase mu 1 (GSTM1) gene has been associated with lung cancer (LC) risk, for GSTM1 enzyme playing a vital role in detoxification pathway and protective against toxic insults. The major objective of this study was to investigate GSTM1 deletion pattern and its association with LC in the world's population by using meta-prediction techniques. The secondary objective was to examine the effects of air pollution, smoking status, and other factors for gene-environment interactions with GSTM1 deletion and LC risk. We completed a comprehensive search to yield a total of 170 studies (40,296 cases and 48,346 controls) published from 1999 to 2017 for metaanalyses. The results revealed that GSTM1 deletion type was associated with increased risk of LC, while GSTM1 present type provided protective effect for all populations combined worldwide. Subgroup analysis on the rank order of risks from highest to lowest, among racial-ethnic groups, were Chinese, South East Asian, other North Asian, European, and finally American. Additional predictive analyses presented that air pollution played a significant role with increased risks of GSTM1 deletion and LC susceptibility, and the risks increased for smokers with higher levels of air pollution. Based on the findings of meta-predictive analysis, increased air pollution levels and smoking status presented additive effects to the LC risk susceptibilities and GSTM1 gene polymorphisms, for gene-environment interactions. Future studies are needed to examine gene-environment interactions for GSTM1 interacting with environmental factors and dietary interventions to mitigate the toxic effects, for LC prevention.",
keywords = "Air pollution, Glutathione S transferase mu 1, Lung cancer, Meta-prediction, Smoking",
author = "Pojui Yu and Kusuma, {Joyce D.} and Suarez, {Maria Aurora R.} and Shiao, {Shyang Yun Pamela Koong}",
year = "2018",
month = "7",
day = "24",
doi = "10.18632/oncotarget.25693",
language = "English (US)",
volume = "9",
pages = "31120--31132",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "57",

}

TY - JOUR

T1 - Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status

T2 - A meta-prediction of worldwide populations

AU - Yu, Pojui

AU - Kusuma, Joyce D.

AU - Suarez, Maria Aurora R.

AU - Shiao, Shyang Yun Pamela Koong

PY - 2018/7/24

Y1 - 2018/7/24

N2 - Glutathione S transferase mu 1 (GSTM1) gene has been associated with lung cancer (LC) risk, for GSTM1 enzyme playing a vital role in detoxification pathway and protective against toxic insults. The major objective of this study was to investigate GSTM1 deletion pattern and its association with LC in the world's population by using meta-prediction techniques. The secondary objective was to examine the effects of air pollution, smoking status, and other factors for gene-environment interactions with GSTM1 deletion and LC risk. We completed a comprehensive search to yield a total of 170 studies (40,296 cases and 48,346 controls) published from 1999 to 2017 for metaanalyses. The results revealed that GSTM1 deletion type was associated with increased risk of LC, while GSTM1 present type provided protective effect for all populations combined worldwide. Subgroup analysis on the rank order of risks from highest to lowest, among racial-ethnic groups, were Chinese, South East Asian, other North Asian, European, and finally American. Additional predictive analyses presented that air pollution played a significant role with increased risks of GSTM1 deletion and LC susceptibility, and the risks increased for smokers with higher levels of air pollution. Based on the findings of meta-predictive analysis, increased air pollution levels and smoking status presented additive effects to the LC risk susceptibilities and GSTM1 gene polymorphisms, for gene-environment interactions. Future studies are needed to examine gene-environment interactions for GSTM1 interacting with environmental factors and dietary interventions to mitigate the toxic effects, for LC prevention.

AB - Glutathione S transferase mu 1 (GSTM1) gene has been associated with lung cancer (LC) risk, for GSTM1 enzyme playing a vital role in detoxification pathway and protective against toxic insults. The major objective of this study was to investigate GSTM1 deletion pattern and its association with LC in the world's population by using meta-prediction techniques. The secondary objective was to examine the effects of air pollution, smoking status, and other factors for gene-environment interactions with GSTM1 deletion and LC risk. We completed a comprehensive search to yield a total of 170 studies (40,296 cases and 48,346 controls) published from 1999 to 2017 for metaanalyses. The results revealed that GSTM1 deletion type was associated with increased risk of LC, while GSTM1 present type provided protective effect for all populations combined worldwide. Subgroup analysis on the rank order of risks from highest to lowest, among racial-ethnic groups, were Chinese, South East Asian, other North Asian, European, and finally American. Additional predictive analyses presented that air pollution played a significant role with increased risks of GSTM1 deletion and LC susceptibility, and the risks increased for smokers with higher levels of air pollution. Based on the findings of meta-predictive analysis, increased air pollution levels and smoking status presented additive effects to the LC risk susceptibilities and GSTM1 gene polymorphisms, for gene-environment interactions. Future studies are needed to examine gene-environment interactions for GSTM1 interacting with environmental factors and dietary interventions to mitigate the toxic effects, for LC prevention.

KW - Air pollution

KW - Glutathione S transferase mu 1

KW - Lung cancer

KW - Meta-prediction

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=85050562929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050562929&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.25693

DO - 10.18632/oncotarget.25693

M3 - Article

AN - SCOPUS:85050562929

VL - 9

SP - 31120

EP - 31132

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 57

ER -