Lung infections: role of apoptosis in host defense and pathogenesis of disease.

M Behnia, K A Robertson, 2nd Martin W J

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Apoptosis is a form of cell death that has gained enormous attention during the past few years, and its mechanisms, important to biology and medicine, are being unraveled at an accelerating pace. Apoptosis of lung cells occurs during lung infections and may be either a host defense mechanism or reflect the pathogenesis of the infection. In the first part of this review, the biochemistry and physiology of apoptotic pathways and its regulators are discussed. This is followed by an overview of apoptotic mechanisms in selected lung infections. The implications of apoptosis in host immunity, pathogenesis, and treatment of pulmonary infections will be discussed in this context.;
Original languageUndefined
Pages (from-to)1771 - 1777
JournalChest
Volume117
Issue number6
Publication statusPublished - 2000

Keywords

  • Apoptosis/*immunology, Pneumonia, Bacterial/*immunology, Pneumonia, Viral/*immunology, Animals, Fas Ligand Protein, Humans, Inflammation Mediators/physiology, Membrane Glycoproteins/physiology, Mitochondria/physiology, Pulmonary Alveoli/physiopathology

Cite this

Behnia, M., Robertson, K. A., & Martin W J, . (2000). Lung infections: role of apoptosis in host defense and pathogenesis of disease. Chest, 117(6), 1771 - 1777.