Lupeol and its ester inhibit alteration of myocardial permeability in cyclophosphamide administered rats

Sudharsan Periyasamy Thandavan, Yenjerla Mythili, Elangovan Selvakumar, Palaninathan Varalakshmi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cyclophosphamide (CP), an alkylating agent widely used in cancer chemotherapy causes cardiac membrane damage. Lupeol, a pentacyclic triterpene, isolated from Crataeva nurvala stem bark and its ester, lupeol linoleate possess a wide range of medicinal properties. The effect of lupeol and its ester was evaluated in CP induced alterations in cardiac electrolytes in rats. Male albino rats of Wistar strain were categorized into 6 groups. Group I served as control. Rats in groups II, V and VI were injected intraperitoneally with a single dose of CP (200 mg/kg body weight) dissolved in saline. CP treated groups V and VI received lupeol and lupeol linoleate (50 mg/kg body weight) respectively, dissolved in olive oil for 10 days by oral gavage. At the end of the experimental period, urinary risk factors, activities of ATPases and electrolytes were measured using standard procedures. CP administered rats showed a significant decrease (P < 0.001) in the activities of ATPases. It was associated with significant alterations (P < 0.001) of electrolytes both in serum and cardiac tissue. The levels of urea, uric acid and creatinine were also significantly (P < 0.001) altered in the serum and urine. Lupeol and its ester showed reversal of the above alterations induced by CP. These findings demonstrate that the supplementation with lupeol and its ester could preserve membrane permeability, highlighting their protective effect against CP induced cardiotoxicity.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume292
Issue number1-2
DOIs
StatePublished - Nov 1 2006

Fingerprint

Cyclophosphamide
Rats
Permeability
Esters
Electrolytes
Adenosine Triphosphatases
Capparaceae
Pentacyclic Triterpenes
Body Weight
Membranes
Chemotherapy
Alkylating Agents
lupeol
Uric Acid
Serum
Urea
Wistar Rats
Creatinine
Urine
Tissue

Keywords

  • Cyclophosphamide
  • Electrolytes
  • Lupeol
  • Lupeollinoleate
  • Membrane permeability

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Lupeol and its ester inhibit alteration of myocardial permeability in cyclophosphamide administered rats. / Periyasamy Thandavan, Sudharsan; Mythili, Yenjerla; Selvakumar, Elangovan; Varalakshmi, Palaninathan.

In: Molecular and Cellular Biochemistry, Vol. 292, No. 1-2, 01.11.2006, p. 39-44.

Research output: Contribution to journalArticle

Periyasamy Thandavan, Sudharsan ; Mythili, Yenjerla ; Selvakumar, Elangovan ; Varalakshmi, Palaninathan. / Lupeol and its ester inhibit alteration of myocardial permeability in cyclophosphamide administered rats. In: Molecular and Cellular Biochemistry. 2006 ; Vol. 292, No. 1-2. pp. 39-44.
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