Lymph node germinal centers form in the absence of follicular dendritic cell networks

Pandelakis A. Koni, Richard A. Flavell

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Follicular dendritic cell networks are said to be pivotal to both the formation of germinal centers (GCs) and their functions in generating antigen-specific antibody affinity maturation and B celt memory. We report that lymphotoxin β-deficient mice form GC cell clusters in the gross anatomical location expected of GCs, despite the complete absence of follicular dendritic cell networks. Furthermore, antigen-specific GC generation was at first relatively normal, but these GCs then rapidly regressed and GC-phase antibody affinity maturation was reduced. Lymphotoxin β-deficient mice also showed substantial B cell memory in their mesenteric lymph nodes. This memory antibody response was of relatively low affinity for antigen at week 4 after challenge, but by week 10 after challenge was comparable to wild-type, indicating that affinity maturation had failed in the GC phase but developed later.

Original languageEnglish (US)
Pages (from-to)855-864
Number of pages10
JournalJournal of Experimental Medicine
Volume189
Issue number5
DOIs
StatePublished - Mar 1 1999

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Follicular Dendritic Cells
Germinal Center
Lymph Nodes
Lymphotoxin-alpha
Antibody Affinity
Antigens
Antibody Formation
B-Lymphocytes

Keywords

  • B cell memory
  • Follicular dendritic cells
  • Germinal centers
  • Knockout mice
  • Lymphotoxin β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lymph node germinal centers form in the absence of follicular dendritic cell networks. / Koni, Pandelakis A.; Flavell, Richard A.

In: Journal of Experimental Medicine, Vol. 189, No. 5, 01.03.1999, p. 855-864.

Research output: Contribution to journalArticle

Koni, Pandelakis A. ; Flavell, Richard A. / Lymph node germinal centers form in the absence of follicular dendritic cell networks. In: Journal of Experimental Medicine. 1999 ; Vol. 189, No. 5. pp. 855-864.
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