OBJECTIVE: Sentinel lymph node biopsy (SLNB) is emerging as an alternative to axillary lymph node dissection (ALND) for many female breast cancer patients. In contrast, ALND remains the standard of care tor male breast patients with similar tumors. We evaluated the results of SLNB in male breast cancer patients with clinically negative axillas. METHODS: The patient population consisted of six consecutive male breast cancer patients, ages 44 to 76 years old, treated at our institution. All patients had negative axillas by clinical exam and ultrasound. Preoperative lymphoscintigraphy was used in all cases. In each patient, 5 cc of isosulfan blue 1% was injected intraoperatively adjacent to the breast tumor or biopsy cavity prior to SLNB. Additionally, Tc-99m sulfur colloid was injected at a dose of 0.5 mCi 4 hours before surgery (2 patients) or 2.5 mCi 24 hours before surgery (4 patients). A gamma probe was used intraoperatively. A SLN was defined as any blue node and/or any node with ex-vivo counts 10x higher than the axillary background. SLNs were assessed intraoperatively by touch prep cytology. Completion ALND was performed in 4 patients. RESULTS: Table 1 summarizes primary tumor characteristics. A mean of 2.2 SLNs per patient was encountered. Lymphoscintigraphy identified SLNs in 4/6 patients preoperatively. Using the gamma probe, SLNs were identified in 5/6 patients. Dye injection identified SLNs in 6/6 patients. Overall, successful SLN localization was accomplished in all cases combining both techniques. Touch prep cytology reports correlated with the final pathological analysis in 6/6 patients. Patients with negative SLNs had no positive nodes in the completion ALND specimens. One patient with a positive SLN had 3 additional positive nodes in the completion ALND specimen. CONCLUSIONS: These data compare favorably with the available literature for SLN biopsy in female breast cancer patients. Blue dye injection and lymphatic mapping were complementary. Performance of SLN biopsy should be considered for the staging of the axilla in male breast cancer patients with clinically negative axillas, SLN biopsy reduces the number of unnecessary ALNDs and could increase the accuracy of the staging of the axilla in these patients. Patienl # 1 2 3 4 5 6 Primary 3.8cm 1.7cm 0.5cm 1.5cm 1.4cm 2.5cm Tumor IDC IDC IDC IDC IDC IDC Pathology Grade 3 Grude 2 Grade 2 Grade 2 Grade 2, Grade 2 ER/PR + ER +; PR - ER +; PR - ER +; PR - ER +; PR - ER/PR + her-2/neu - her-2/neu + her-2/neu -.
|Original language||English (US)|
|Number of pages||1|
|Journal||Breast Cancer Research and Treatment|
|Publication status||Published - Dec 1 2001|
ASJC Scopus subject areas
- Cancer Research