Lymphoepithelial carcinoma of the parotid gland

Background. Primary lymphoepithelial carcinoma of the parotid gland is a rare tumor with an increased incidence among Eskimos and Orientals. We reviewed our experience with parotid lymphoepithelial carcinoma and investigated its pathophysiology and possible association with Epstein‐Barr virus. Methods. We performed a retrospective review of records of patients diagnosed with lymphoepithelial carcinoma of the parotid gland. Results. We identified two women of Hispanic origin diagnosed with primary lymphoepithelial carcinoma of the parotid gland. In one of the cases, the carcinoma was intimately associated with a benign lymphoepithelial lesion. In both cases, there was no demonstration of Epstein‐Barr virus. Conclusion. Primary lymphoepithelial carcinoma of the parotid gland may arise from malignant transformation of a benign lymphoepithelial lesion. © 1995 Jons Wiley & Sons, Inc.