Lymphotoxin-β-deficient mice show defective antiviral immunity

Dietmar P. Berger, Denise Naniche, Mary T. Crowley, Pandelakis A. Koni, Richard A. Flavell, Michael B.A. Oldstone

Research output: Contribution to journalArticle

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Abstract

Lymphotoxin β (LTβ), a member of the tumor necrosis factor family, plays an important role in lymphoid organogenesis. In order to determine whether LTβ is involved in cellular immunity, we investigated the antiviral immune response of LTβ-deficient (LTβ -/-) mice to lymphocytic choriomeningitis virus (LCMV). Cytotoxic T lymphocyte (CTL) responses to LCMV were severely diminished, leading to viral persistence in brain and kidney. However, major functions of LTβ-deficient T lymphocytes and dendritic cells were intact. Reconstitution of irradiated LTβ +/+ mice with LTβ -/- bone marrow induced a disorganized splenic structure, accompanied by impairment of the LCMV-specific CTL response. These data indicate that the absence of LTβ does not affect the intrinsic function of T lymphocytes or of dendritic cells but that the structural integrity of the spleen is strongly associated with generation of antiviral immunity.

Original languageEnglish (US)
Pages (from-to)136-147
Number of pages12
JournalVirology
Volume260
Issue number1
DOIs
StatePublished - Jul 20 1999

Fingerprint

Lymphotoxin-alpha
Antiviral Agents
Immunity
Lymphocytic choriomeningitis virus
Cytotoxic T-Lymphocytes
Dendritic Cells
T-Lymphocytes
Organogenesis
Cellular Immunity
Spleen
Tumor Necrosis Factor-alpha
Bone Marrow
Kidney
Brain

Keywords

  • CTL
  • Cell surface molecules
  • Dendritic cells
  • Lymphoid organization

ASJC Scopus subject areas

  • Virology

Cite this

Berger, D. P., Naniche, D., Crowley, M. T., Koni, P. A., Flavell, R. A., & Oldstone, M. B. A. (1999). Lymphotoxin-β-deficient mice show defective antiviral immunity. Virology, 260(1), 136-147. https://doi.org/10.1006/viro.1999.9811

Lymphotoxin-β-deficient mice show defective antiviral immunity. / Berger, Dietmar P.; Naniche, Denise; Crowley, Mary T.; Koni, Pandelakis A.; Flavell, Richard A.; Oldstone, Michael B.A.

In: Virology, Vol. 260, No. 1, 20.07.1999, p. 136-147.

Research output: Contribution to journalArticle

Berger, DP, Naniche, D, Crowley, MT, Koni, PA, Flavell, RA & Oldstone, MBA 1999, 'Lymphotoxin-β-deficient mice show defective antiviral immunity', Virology, vol. 260, no. 1, pp. 136-147. https://doi.org/10.1006/viro.1999.9811
Berger DP, Naniche D, Crowley MT, Koni PA, Flavell RA, Oldstone MBA. Lymphotoxin-β-deficient mice show defective antiviral immunity. Virology. 1999 Jul 20;260(1):136-147. https://doi.org/10.1006/viro.1999.9811
Berger, Dietmar P. ; Naniche, Denise ; Crowley, Mary T. ; Koni, Pandelakis A. ; Flavell, Richard A. ; Oldstone, Michael B.A. / Lymphotoxin-β-deficient mice show defective antiviral immunity. In: Virology. 1999 ; Vol. 260, No. 1. pp. 136-147.
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