Lymphotoxin-β-deficient mice show defective antiviral immunity

Dietmar P. Berger, Denise Naniche, Mary T. Crowley, Pandelakis A. Koni, Richard A. Flavell, Michael B.A. Oldstone

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Lymphotoxin β (LTβ), a member of the tumor necrosis factor family, plays an important role in lymphoid organogenesis. In order to determine whether LTβ is involved in cellular immunity, we investigated the antiviral immune response of LTβ-deficient (LTβ -/-) mice to lymphocytic choriomeningitis virus (LCMV). Cytotoxic T lymphocyte (CTL) responses to LCMV were severely diminished, leading to viral persistence in brain and kidney. However, major functions of LTβ-deficient T lymphocytes and dendritic cells were intact. Reconstitution of irradiated LTβ +/+ mice with LTβ -/- bone marrow induced a disorganized splenic structure, accompanied by impairment of the LCMV-specific CTL response. These data indicate that the absence of LTβ does not affect the intrinsic function of T lymphocytes or of dendritic cells but that the structural integrity of the spleen is strongly associated with generation of antiviral immunity.

Original languageEnglish (US)
Pages (from-to)136-147
Number of pages12
JournalVirology
Volume260
Issue number1
DOIs
StatePublished - Jul 20 1999

Keywords

  • CTL
  • Cell surface molecules
  • Dendritic cells
  • Lymphoid organization

ASJC Scopus subject areas

  • Virology

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  • Cite this

    Berger, D. P., Naniche, D., Crowley, M. T., Koni, P. A., Flavell, R. A., & Oldstone, M. B. A. (1999). Lymphotoxin-β-deficient mice show defective antiviral immunity. Virology, 260(1), 136-147. https://doi.org/10.1006/viro.1999.9811