Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity

Shogo Mori; Howard Williams; Davey Cagle; Kristopher Karanovich; F. David Horgen; Roger Smith; Coran M.H. Watanabe

doi:10.3390/md13106274

Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity

Shogo Mori, Howard Williams, Davey Cagle, Kristopher Karanovich, F. David Horgen, Roger Smith, Coran M.H. Watanabe

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

Original language	English (US)
Pages (from-to)	6274-6290
Number of pages	17
Journal	Marine Drugs
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/md13106274
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Cell cycle
Chemotaxis
Cyanobacteria
Macrolactone
Polyketide

ASJC Scopus subject areas

Drug Discovery

Access to Document

10.3390/md13106274

Cite this

@article{65fb768a6ac546c18286088743bb173b,

title = "Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity",

abstract = "A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.",

keywords = "Cell cycle, Chemotaxis, Cyanobacteria, Macrolactone, Polyketide",

author = "Shogo Mori and Howard Williams and Davey Cagle and Kristopher Karanovich and Horgen, {F. David} and Roger Smith and Watanabe, {Coran M.H.}",

note = "Publisher Copyright: {\textcopyright} 2015 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2015",

month = oct,

day = "1",

doi = "10.3390/md13106274",

language = "English (US)",

volume = "13",

pages = "6274--6290",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity

AU - Mori, Shogo

AU - Williams, Howard

AU - Cagle, Davey

AU - Karanovich, Kristopher

AU - Horgen, F. David

AU - Smith, Roger

AU - Watanabe, Coran M.H.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

AB - A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

KW - Cell cycle

KW - Chemotaxis

KW - Cyanobacteria

KW - Macrolactone

KW - Polyketide

UR - http://www.scopus.com/inward/record.url?scp=84945891978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945891978&partnerID=8YFLogxK

U2 - 10.3390/md13106274

DO - 10.3390/md13106274

M3 - Review article

C2 - 26473885

AN - SCOPUS:84945891978

SN - 1660-3397

VL - 13

SP - 6274

EP - 6290

JO - Marine Drugs

JF - Marine Drugs

IS - 10

ER -

Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this