Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity

Shogo Mori, Howard Williams, Davey Cagle, Kristopher Karanovich, F. David Horgen, Roger Smith, Coran M.H. Watanabe

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

Original languageEnglish (US)
Pages (from-to)6274-6290
Number of pages17
JournalMarine Drugs
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Cell cycle
  • Chemotaxis
  • Cyanobacteria
  • Macrolactone
  • Polyketide

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint Dive into the research topics of 'Macrolactone nuiapolide, isolated from a Hawaiian marine cyanobacterium, exhibits anti-chemotactic activity'. Together they form a unique fingerprint.

Cite this