Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis

William H. Hoffman, K. T. Kovacs, R. R. Gala, Brooks Allen Keel, T. S. Jarrell, J. O. Ellegood, C. L. Burek

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A 16-year-old male with long-standing atrophic chronic lymphocytic thyroiditis was evaluated for macroorchidism. A testicular biopsy prior to treatment revealed peritubular and interstitial fibrosis, reduced spermatogenesis and sparse Leydig cells with nonprominent smooth endoplasmic reticulum. Biological/immunological LH and FSH ratios were reduced, l-LH and FSH response to GnRH was blunted, and levels of testosterone and androstenedione were low. Twenty-two months after thyroid treatment, the testicular size was unchanged, and the degree of fibrosis showed minimal regression. Spermatogenesis with normal morphology was present, Leydig cells with Reinke crystals were present, and surface area and diameter of the seminiferous tubules had increased only slightly. There was a normal l-LH and FSH response to GnRH, and normal levels of testosterone and androstenedione. This study, along with previous reports, suggests that the etiology of the hypothyroid state may influence the development of testicular fibrosis.

Original languageEnglish (US)
Pages (from-to)609-616
Number of pages8
JournalJournal of Endocrinological Investigation
Volume14
Issue number7
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Autoimmune Thyroiditis
Fibrosis
Leydig Cells
Androstenedione
Spermatogenesis
Gonadotropin-Releasing Hormone
Testosterone
Smooth Endoplasmic Reticulum
Hashimoto Disease
Seminiferous Tubules
Thyroid Gland
Biopsy

Keywords

  • Autoimmune thyroiditis
  • hypothyroid
  • macroorchidism
  • testicular fibrosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Hoffman, W. H., Kovacs, K. T., Gala, R. R., Keel, B. A., Jarrell, T. S., Ellegood, J. O., & Burek, C. L. (1991). Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis. Journal of Endocrinological Investigation, 14(7), 609-616. https://doi.org/10.1007/BF03346881

Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis. / Hoffman, William H.; Kovacs, K. T.; Gala, R. R.; Keel, Brooks Allen; Jarrell, T. S.; Ellegood, J. O.; Burek, C. L.

In: Journal of Endocrinological Investigation, Vol. 14, No. 7, 01.01.1991, p. 609-616.

Research output: Contribution to journalArticle

Hoffman, WH, Kovacs, KT, Gala, RR, Keel, BA, Jarrell, TS, Ellegood, JO & Burek, CL 1991, 'Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis', Journal of Endocrinological Investigation, vol. 14, no. 7, pp. 609-616. https://doi.org/10.1007/BF03346881
Hoffman, William H. ; Kovacs, K. T. ; Gala, R. R. ; Keel, Brooks Allen ; Jarrell, T. S. ; Ellegood, J. O. ; Burek, C. L. / Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis. In: Journal of Endocrinological Investigation. 1991 ; Vol. 14, No. 7. pp. 609-616.
@article{f19f35c6e1994117a6bdc5595e010270,
title = "Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis",
abstract = "A 16-year-old male with long-standing atrophic chronic lymphocytic thyroiditis was evaluated for macroorchidism. A testicular biopsy prior to treatment revealed peritubular and interstitial fibrosis, reduced spermatogenesis and sparse Leydig cells with nonprominent smooth endoplasmic reticulum. Biological/immunological LH and FSH ratios were reduced, l-LH and FSH response to GnRH was blunted, and levels of testosterone and androstenedione were low. Twenty-two months after thyroid treatment, the testicular size was unchanged, and the degree of fibrosis showed minimal regression. Spermatogenesis with normal morphology was present, Leydig cells with Reinke crystals were present, and surface area and diameter of the seminiferous tubules had increased only slightly. There was a normal l-LH and FSH response to GnRH, and normal levels of testosterone and androstenedione. This study, along with previous reports, suggests that the etiology of the hypothyroid state may influence the development of testicular fibrosis.",
keywords = "Autoimmune thyroiditis, hypothyroid, macroorchidism, testicular fibrosis",
author = "Hoffman, {William H.} and Kovacs, {K. T.} and Gala, {R. R.} and Keel, {Brooks Allen} and Jarrell, {T. S.} and Ellegood, {J. O.} and Burek, {C. L.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1007/BF03346881",
language = "English (US)",
volume = "14",
pages = "609--616",
journal = "Journal of Endocrinological Investigation",
issn = "0391-4097",
publisher = "Editrice Kurtis s.r.l.",
number = "7",

}

TY - JOUR

T1 - Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis

AU - Hoffman, William H.

AU - Kovacs, K. T.

AU - Gala, R. R.

AU - Keel, Brooks Allen

AU - Jarrell, T. S.

AU - Ellegood, J. O.

AU - Burek, C. L.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A 16-year-old male with long-standing atrophic chronic lymphocytic thyroiditis was evaluated for macroorchidism. A testicular biopsy prior to treatment revealed peritubular and interstitial fibrosis, reduced spermatogenesis and sparse Leydig cells with nonprominent smooth endoplasmic reticulum. Biological/immunological LH and FSH ratios were reduced, l-LH and FSH response to GnRH was blunted, and levels of testosterone and androstenedione were low. Twenty-two months after thyroid treatment, the testicular size was unchanged, and the degree of fibrosis showed minimal regression. Spermatogenesis with normal morphology was present, Leydig cells with Reinke crystals were present, and surface area and diameter of the seminiferous tubules had increased only slightly. There was a normal l-LH and FSH response to GnRH, and normal levels of testosterone and androstenedione. This study, along with previous reports, suggests that the etiology of the hypothyroid state may influence the development of testicular fibrosis.

AB - A 16-year-old male with long-standing atrophic chronic lymphocytic thyroiditis was evaluated for macroorchidism. A testicular biopsy prior to treatment revealed peritubular and interstitial fibrosis, reduced spermatogenesis and sparse Leydig cells with nonprominent smooth endoplasmic reticulum. Biological/immunological LH and FSH ratios were reduced, l-LH and FSH response to GnRH was blunted, and levels of testosterone and androstenedione were low. Twenty-two months after thyroid treatment, the testicular size was unchanged, and the degree of fibrosis showed minimal regression. Spermatogenesis with normal morphology was present, Leydig cells with Reinke crystals were present, and surface area and diameter of the seminiferous tubules had increased only slightly. There was a normal l-LH and FSH response to GnRH, and normal levels of testosterone and androstenedione. This study, along with previous reports, suggests that the etiology of the hypothyroid state may influence the development of testicular fibrosis.

KW - Autoimmune thyroiditis

KW - hypothyroid

KW - macroorchidism

KW - testicular fibrosis

UR - http://www.scopus.com/inward/record.url?scp=0025777020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025777020&partnerID=8YFLogxK

U2 - 10.1007/BF03346881

DO - 10.1007/BF03346881

M3 - Article

VL - 14

SP - 609

EP - 616

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

IS - 7

ER -