Macrophages and the regulation of self-reactive T cells

David H. Munn, Andrew L. Mellor

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalCurrent Pharmaceutical Design
Volume9
Issue number3
DOIs
StatePublished - Feb 3 2003

Fingerprint

Macrophages
T-Lymphocytes
Autoantigens
Antigen-Presenting Cells
Immunosuppressive Agents
Autoimmunity
Inflammation

Keywords

  • Autoimmunity
  • Immune tolerance
  • Indoleamine 2,3-dioxygenase
  • Macrophages
  • Self tolerance
  • T cells
  • Tryptophan

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Macrophages and the regulation of self-reactive T cells. / Munn, David H.; Mellor, Andrew L.

In: Current Pharmaceutical Design, Vol. 9, No. 3, 03.02.2003, p. 257-264.

Research output: Contribution to journalReview article

@article{f74a6735c9724dd18c35da8d6e3f7a7d,
title = "Macrophages and the regulation of self-reactive T cells",
abstract = "Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity.",
keywords = "Autoimmunity, Immune tolerance, Indoleamine 2,3-dioxygenase, Macrophages, Self tolerance, T cells, Tryptophan",
author = "Munn, {David H.} and Mellor, {Andrew L.}",
year = "2003",
month = "2",
day = "3",
doi = "10.2174/1381612033392026",
language = "English (US)",
volume = "9",
pages = "257--264",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Macrophages and the regulation of self-reactive T cells

AU - Munn, David H.

AU - Mellor, Andrew L.

PY - 2003/2/3

Y1 - 2003/2/3

N2 - Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity.

AB - Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity.

KW - Autoimmunity

KW - Immune tolerance

KW - Indoleamine 2,3-dioxygenase

KW - Macrophages

KW - Self tolerance

KW - T cells

KW - Tryptophan

UR - http://www.scopus.com/inward/record.url?scp=0037239156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037239156&partnerID=8YFLogxK

U2 - 10.2174/1381612033392026

DO - 10.2174/1381612033392026

M3 - Review article

VL - 9

SP - 257

EP - 264

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 3

ER -