Magnetic resonance imaging in childhood intractable partial epilepsies: Pathologic correlations

Ruben Kuzniecky, Anthony M Murro, D. King, R. Morawetz, J. Smith, R. Powers, F. Yaghmai, E. Faught, B. Gallagher, O. C. Snead

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases. MRI revealed abnormalities in concordance with the clinical and electroencephalographic data in 84% of patients. Developmental neuronal migration pathology was present in 25% of patients and was relatively more common in the sensorimotor cortex. There was hippocampal sclerosis in 50% of patients with temporal lobe resection; however, only two of the 10 children with hippocampal sclerosis were below the age of 12 years. Similarly, ganglioglial tumors were more common than astrocytomas in children below age 12. These results indicate that MRI is sensitive in the detection of pathologic abnormalities in most pediatric candidates for epilepsy surgery, and that the distribution and type of pathology appear to be age related in this population.

Original languageEnglish (US)
Pages (from-to)681-687
Number of pages7
JournalNeurology
Volume43
Issue number4
StatePublished - Jan 1 1993

Fingerprint

Partial Epilepsy
Magnetic Resonance Imaging
Sclerosis
Pathology
Single-Blind Method
Astrocytoma
Temporal Lobe
Epilepsy
Pediatrics
Population
Drug Resistant Epilepsy
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Kuzniecky, R., Murro, A. M., King, D., Morawetz, R., Smith, J., Powers, R., ... Snead, O. C. (1993). Magnetic resonance imaging in childhood intractable partial epilepsies: Pathologic correlations. Neurology, 43(4), 681-687.

Magnetic resonance imaging in childhood intractable partial epilepsies : Pathologic correlations. / Kuzniecky, Ruben; Murro, Anthony M; King, D.; Morawetz, R.; Smith, J.; Powers, R.; Yaghmai, F.; Faught, E.; Gallagher, B.; Snead, O. C.

In: Neurology, Vol. 43, No. 4, 01.01.1993, p. 681-687.

Research output: Contribution to journalArticle

Kuzniecky, R, Murro, AM, King, D, Morawetz, R, Smith, J, Powers, R, Yaghmai, F, Faught, E, Gallagher, B & Snead, OC 1993, 'Magnetic resonance imaging in childhood intractable partial epilepsies: Pathologic correlations', Neurology, vol. 43, no. 4, pp. 681-687.
Kuzniecky R, Murro AM, King D, Morawetz R, Smith J, Powers R et al. Magnetic resonance imaging in childhood intractable partial epilepsies: Pathologic correlations. Neurology. 1993 Jan 1;43(4):681-687.
Kuzniecky, Ruben ; Murro, Anthony M ; King, D. ; Morawetz, R. ; Smith, J. ; Powers, R. ; Yaghmai, F. ; Faught, E. ; Gallagher, B. ; Snead, O. C. / Magnetic resonance imaging in childhood intractable partial epilepsies : Pathologic correlations. In: Neurology. 1993 ; Vol. 43, No. 4. pp. 681-687.
@article{b7b941121590414f829b513716ebc4e3,
title = "Magnetic resonance imaging in childhood intractable partial epilepsies: Pathologic correlations",
abstract = "We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases. MRI revealed abnormalities in concordance with the clinical and electroencephalographic data in 84{\%} of patients. Developmental neuronal migration pathology was present in 25{\%} of patients and was relatively more common in the sensorimotor cortex. There was hippocampal sclerosis in 50{\%} of patients with temporal lobe resection; however, only two of the 10 children with hippocampal sclerosis were below the age of 12 years. Similarly, ganglioglial tumors were more common than astrocytomas in children below age 12. These results indicate that MRI is sensitive in the detection of pathologic abnormalities in most pediatric candidates for epilepsy surgery, and that the distribution and type of pathology appear to be age related in this population.",
author = "Ruben Kuzniecky and Murro, {Anthony M} and D. King and R. Morawetz and J. Smith and R. Powers and F. Yaghmai and E. Faught and B. Gallagher and Snead, {O. C.}",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "43",
pages = "681--687",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Magnetic resonance imaging in childhood intractable partial epilepsies

T2 - Pathologic correlations

AU - Kuzniecky, Ruben

AU - Murro, Anthony M

AU - King, D.

AU - Morawetz, R.

AU - Smith, J.

AU - Powers, R.

AU - Yaghmai, F.

AU - Faught, E.

AU - Gallagher, B.

AU - Snead, O. C.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases. MRI revealed abnormalities in concordance with the clinical and electroencephalographic data in 84% of patients. Developmental neuronal migration pathology was present in 25% of patients and was relatively more common in the sensorimotor cortex. There was hippocampal sclerosis in 50% of patients with temporal lobe resection; however, only two of the 10 children with hippocampal sclerosis were below the age of 12 years. Similarly, ganglioglial tumors were more common than astrocytomas in children below age 12. These results indicate that MRI is sensitive in the detection of pathologic abnormalities in most pediatric candidates for epilepsy surgery, and that the distribution and type of pathology appear to be age related in this population.

AB - We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases. MRI revealed abnormalities in concordance with the clinical and electroencephalographic data in 84% of patients. Developmental neuronal migration pathology was present in 25% of patients and was relatively more common in the sensorimotor cortex. There was hippocampal sclerosis in 50% of patients with temporal lobe resection; however, only two of the 10 children with hippocampal sclerosis were below the age of 12 years. Similarly, ganglioglial tumors were more common than astrocytomas in children below age 12. These results indicate that MRI is sensitive in the detection of pathologic abnormalities in most pediatric candidates for epilepsy surgery, and that the distribution and type of pathology appear to be age related in this population.

UR - http://www.scopus.com/inward/record.url?scp=0027516957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027516957&partnerID=8YFLogxK

M3 - Article

C2 - 8469322

AN - SCOPUS:0027516957

VL - 43

SP - 681

EP - 687

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -