Abstract
Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-84 |
| Number of pages | 23 |
| Journal | Experimental eye research |
| Volume | 160 |
| DOIs | |
| State | Published - Jul 1 2017 |
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Keywords
- Association
- Differential expression
- Endophenotype
- GWAS
- Genetics
- Glaucoma
- Linkage
- POAG
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Major review : Molecular genetics of primary open-angle glaucoma. / Liu, Yutao; Allingham, R. Rand.
In: Experimental eye research, Vol. 160, 01.07.2017, p. 62-84.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Major review
T2 - Molecular genetics of primary open-angle glaucoma
AU - Liu, Yutao
AU - Allingham, R. Rand
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.
AB - Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.
KW - Association
KW - Differential expression
KW - Endophenotype
KW - GWAS
KW - Genetics
KW - Glaucoma
KW - Linkage
KW - POAG
UR - http://www.scopus.com/inward/record.url?scp=85019846690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019846690&partnerID=8YFLogxK
U2 - 10.1016/j.exer.2017.05.002
DO - 10.1016/j.exer.2017.05.002
M3 - Review article
C2 - 28499933
AN - SCOPUS:85019846690
VL - 160
SP - 62
EP - 84
JO - Experimental Eye Research
JF - Experimental Eye Research
SN - 0014-4835
ER -