Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl

Nisha J. D'Silva, Zoya Bronislavovna Kurago, Peter J. Polverini, Carl T. Hanks, Augusto F. Paulino

Research output: Contribution to journalArticle

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Abstract

Mucosal melanomas of the oral cavity are rarely seen in the United States. The hard palate is the most common intraoral site. This unusual case occurred in the oral cavity of a 17-year-old Asian girl, who presented to her dentist with complaints of pain and swelling in the upper jaw. The lesion was distal and palatal to the maxillary left second molar, which was vital. Interestingly, the clinical presentation was a hyperplastic, tender lesion that bled when probed. Histopathologically, the biopsy demonstrated a sheet of spindle-shaped cells arranged in nests and fascicles. The nuclei were vesicular, oval to spindle-shaped, and some contained nucleoli that were distinguishable but not prominent. No melanin pigment was observed in the lesion. Tumor cells strongly expressed S100 protein, gp100 (HMB-45), and microphthalmia transcription factor, and variably expressed MART1, but not cytokeratins, CD34, or muscle-specific actin. The histopathologic features and immunohistochemical findings are consistent with a diagnosis of malignant melanoma.

Original languageEnglish (US)
Pages (from-to)1110-1113
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume126
Issue number9
StatePublished - Sep 1 2002

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Mouth Mucosa
Mouth
Melanoma
Microphthalmia-Associated Transcription Factor
Hard Palate
S100 Proteins
Melanins
Maxilla
Keratins
Dentists
Actins
Biopsy
Pain
Muscles
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

D'Silva, N. J., Kurago, Z. B., Polverini, P. J., Hanks, C. T., & Paulino, A. F. (2002). Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl. Archives of Pathology and Laboratory Medicine, 126(9), 1110-1113.

Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl. / D'Silva, Nisha J.; Kurago, Zoya Bronislavovna; Polverini, Peter J.; Hanks, Carl T.; Paulino, Augusto F.

In: Archives of Pathology and Laboratory Medicine, Vol. 126, No. 9, 01.09.2002, p. 1110-1113.

Research output: Contribution to journalArticle

D'Silva, NJ, Kurago, ZB, Polverini, PJ, Hanks, CT & Paulino, AF 2002, 'Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl', Archives of Pathology and Laboratory Medicine, vol. 126, no. 9, pp. 1110-1113.
D'Silva, Nisha J. ; Kurago, Zoya Bronislavovna ; Polverini, Peter J. ; Hanks, Carl T. ; Paulino, Augusto F. / Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl. In: Archives of Pathology and Laboratory Medicine. 2002 ; Vol. 126, No. 9. pp. 1110-1113.
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