Malignant tranformation of a papilloma induced by bovine papillomavirus type 4 in the nude mouse renal capsule

J. Gaukroger, L. Chandrachud, W. F.H. Jarrett, G. E. McGarvie, W. A. Yeudall, R. E. McCaffery, K. T. Smith, M. S. Campo

Research output: Contribution to journalArticle

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Abstract

A papillomatous cyst was induced by implanting bovine foetal palate epithelium, infected in vitro with bovine papillomavirus type 4 (BPV-4), beneath the renal capsule of a nude mouse. The benign tumour underwent malignant progression, developing into a squamous cell carcinoma with metastatic deposits in the spleen. The bovine origin of both the renal and splenic cancers was confirmed by the presence of bovine major histocompatibility complex class I antigens in the cancer cells and by sequencing the Harvey-ras 1 gene, which was shown to be of bovine origin. BPV-4 DNA was present in the residual papillomatous fronds of the renal cancer, but was absent from the carcinoma proper and for the splenic metastasis. These results confirm that BPV-4 is a carcinogenic agent and that its genetic information is not necessary for the maintenance of the malignant phenotype. Moreover th system provides the opportunity to investigate the role of viral and chemical carcinogens in an experimental system.

Original languageEnglish (US)
Pages (from-to)1165-1168
Number of pages4
JournalJournal of General Virology
Volume72
Issue number5
DOIs
StatePublished - Jan 1 1991

Fingerprint

Bovine papillomavirus 4
Papilloma
Nude Mice
Capsules
Kidney
Kidney Neoplasms
Splenic Neoplasms
Histocompatibility Antigens Class I
ras Genes
Palate
Major Histocompatibility Complex
Carcinogens
Cysts
Squamous Cell Carcinoma
Neoplasms
Spleen
Epithelium
Maintenance
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Virology

Cite this

Gaukroger, J., Chandrachud, L., Jarrett, W. F. H., McGarvie, G. E., Yeudall, W. A., McCaffery, R. E., ... Campo, M. S. (1991). Malignant tranformation of a papilloma induced by bovine papillomavirus type 4 in the nude mouse renal capsule. Journal of General Virology, 72(5), 1165-1168. https://doi.org/10.1099/0022-1317-72-5-1165

Malignant tranformation of a papilloma induced by bovine papillomavirus type 4 in the nude mouse renal capsule. / Gaukroger, J.; Chandrachud, L.; Jarrett, W. F.H.; McGarvie, G. E.; Yeudall, W. A.; McCaffery, R. E.; Smith, K. T.; Campo, M. S.

In: Journal of General Virology, Vol. 72, No. 5, 01.01.1991, p. 1165-1168.

Research output: Contribution to journalArticle

Gaukroger, J, Chandrachud, L, Jarrett, WFH, McGarvie, GE, Yeudall, WA, McCaffery, RE, Smith, KT & Campo, MS 1991, 'Malignant tranformation of a papilloma induced by bovine papillomavirus type 4 in the nude mouse renal capsule', Journal of General Virology, vol. 72, no. 5, pp. 1165-1168. https://doi.org/10.1099/0022-1317-72-5-1165
Gaukroger, J. ; Chandrachud, L. ; Jarrett, W. F.H. ; McGarvie, G. E. ; Yeudall, W. A. ; McCaffery, R. E. ; Smith, K. T. ; Campo, M. S. / Malignant tranformation of a papilloma induced by bovine papillomavirus type 4 in the nude mouse renal capsule. In: Journal of General Virology. 1991 ; Vol. 72, No. 5. pp. 1165-1168.
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