Mammalian cell-cycle regulation: Several cdks, numerous cyclins and diverse compensatory mechanisms

A. Satyanarayana, P. Kaldis

Research output: Contribution to journalReview articlepeer-review

447 Scopus citations

Abstract

After a decade of extensive work on gene knockout mouse models of cell-cycle regulators, the classical model of cell-cycle regulation was seriously challenged. Several unexpected compensatory mechanisms were uncovered among cyclins and Cdks in these studies. The most astonishing observation is that Cdk2 is dispensable for the regulation of the mitotic cell cycle with both Cdk4 and Cdk1 covering for Cdk2's functions. Similar to yeast, it was recently discovered that Cdk1 alone can drive the mammalian cell cycle, indicating that the regulation of the mammalian cell cycle is highly conserved. Nevertheless, cell-cycle-independent functions of Cdks and cyclins such as in DNA damage repair are still under investigation. Here we review the compensatory mechanisms among major cyclins and Cdks in mammalian cell-cycle regulation.

Original languageEnglish (US)
Pages (from-to)2925-2939
Number of pages15
JournalOncogene
Volume28
Issue number33
DOIs
StatePublished - Aug 20 2009

Keywords

  • Cdk
  • Cell cycle
  • Cyclin
  • DNA damage
  • Knockout mouse
  • Meiosis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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