Management of metastatic spinal cord compression

Quaovi Sodji, Joseph Kaminski, Christopher Willey, Nathan Kim, Waleed Mourad, John Vender, Byron Dasher

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Cancer metastasis is a key event in tumor progression associated not only with mortality but also significant morbidity. Metastatic disease can promote end-organ dysfunction and even failure through mass effect compression of various vital organs including the spinal cord. In such cases, prompt medical attention is needed to restore neurological function, relieve pain, and prevent permanent damage. The three therapeutic approaches to managing metastatic spinal cord compression include corticosteroids, surgery, and radiation therapy. Although each may improve patients' symptoms, their combination has yielded the best outcome. In cancer patients with clinical suspicion of spinal cord compression, dexamethasone should be initiated followed by surgical decompression, when possible, and radiation. The latter becomes the preferred treatment in patients with inoperable disease.

Original languageEnglish (US)
Pages (from-to)586-593
Number of pages8
JournalSouthern medical journal
Volume110
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • Cancer metastasis
  • Radiation therapy
  • Spinal cord compression
  • Stereotactic body radiotherapy

ASJC Scopus subject areas

  • Medicine(all)

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    Sodji, Q., Kaminski, J., Willey, C., Kim, N., Mourad, W., Vender, J., & Dasher, B. (2017). Management of metastatic spinal cord compression. Southern medical journal, 110(9), 586-593. https://doi.org/10.14423/SMJ.0000000000000700