Management of sarcomatoid salivary duct carcinoma of the submandibular gland duct with coexisting seropositive human immunodeficiency virus

W. F. Mourad, K. S. Hu, R. A. Shourbaji, L. B. Harrison

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Sarcomatoid salivary duct carcinoma of the submandibular gland is extremely rare. This paper highlights the impact of surgery and adjuvant radiation therapy on the outcome of this disease. Methods: A 59-year-old man with human immunodeficiency virus presented with a painless, rapidly growing left neck mass. Biopsy followed by surgical excision of the left submandibular gland revealed sarcomatoid salivary duct carcinoma of the submandibular gland duct with perineural invasion and close margins, for which he underwent adjuvant radiotherapy. Post-operative positron emission tomography and computed tomography revealed no residual or metastatic disease. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 M0 (stage II) tumour. Results: The patient tolerated his treatment without serious acute or long-term side effects. There was no evidence of disease on comprehensive examination or on positron emission tomography or computed tomography scans at the 4.6-year follow up. Conclusion: Surgery followed by adjuvant radiotherapy provided practical locoregional control with acceptable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalJournal of Laryngology and Otology
Volume127
Issue number6
DOIs
StatePublished - Jun 1 2013

Keywords

  • Carcinoma
  • Human Immunodeficiency Virus
  • Pathology
  • Radiotherapy
  • Salivary Ducts
  • Submandibular Gland

ASJC Scopus subject areas

  • Otorhinolaryngology

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