Management of thrombocytopenia in advanced liver disease

V. G.R. Gangireddy, P. C. Kanneganti, Subbaramiah Sridhar, S. Talla, T. Coleman

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Thrombocytopenia (defined as a platelet count <150×109/L) is a wellknown complication in patients with liver cirrhosis and has been observed in 76% to 85% of patients. Significant thrombocytopenia (platelet count <50×109/L to 75×109/L) occurs in approximately 13% of patients with cirrhosis. Thrombocytopenia can negatively impact the care of patients with severe liver disease by potentially interfering with diagnostic and therapeutic procedures. Multiple factors can contribute to the development of thrombocytopenia including splenic platelet sequestration, immunological processes, bone marrow suppression by chronic viral infection, and reduced levels or activity of the hematopoietic growth factor thrombopoietin. The present review focuses on the etiologies and management options for severe thrombocytopenia in the setting of advanced liver disease.

Original languageEnglish (US)
Pages (from-to)558-564
Number of pages7
JournalCanadian Journal of Gastroenterology and Hepatology
Volume28
Issue number10
DOIs
StatePublished - Nov 1 2014

Fingerprint

Thrombocytopenia
Liver Diseases
Platelet Count
Thrombopoietin
Virus Diseases
Liver Cirrhosis
Intercellular Signaling Peptides and Proteins
Patient Care
Fibrosis
Blood Platelets
Bone Marrow
Therapeutics

Keywords

  • Advanced liver disease
  • Cirrhosis
  • Splenectomy
  • Splenic artery embolization
  • Thrombocytopenia
  • Thrombopoietin stmulators

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Management of thrombocytopenia in advanced liver disease. / Gangireddy, V. G.R.; Kanneganti, P. C.; Sridhar, Subbaramiah; Talla, S.; Coleman, T.

In: Canadian Journal of Gastroenterology and Hepatology, Vol. 28, No. 10, 01.11.2014, p. 558-564.

Research output: Contribution to journalReview article

Gangireddy, V. G.R. ; Kanneganti, P. C. ; Sridhar, Subbaramiah ; Talla, S. ; Coleman, T. / Management of thrombocytopenia in advanced liver disease. In: Canadian Journal of Gastroenterology and Hepatology. 2014 ; Vol. 28, No. 10. pp. 558-564.
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