Marrow cytokine transcripts and the secondary hematologic disorders

Harvey D. Preisler, Xue Zhi Gao, Tao Ming, Biaoru Li, Sucai Bi, Emmanuelle Devemy, Jerome Loew, Azra Raza

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A comparison was made of the cytokine transcripts in normal, monoclonal, MDS, and AML marrow aspirates. While both normal and monoclonal marrow aspirates contain transcripts for SCF, few MDS or AML marrow aspirates contain these transcripts. Similarly, IL1ra transcripts are found with reduced frequency in MDS and AML marrow aspirates. The fall in SCF transcripts between monoclonal and MDS marrow aspirates parallels the appearance of apoptosis and the reduced in vitro proliferative ability which are characteristics of MDS marrow aspirate cells. The frequent IL1β production by MDS and AML marrow aspirate cells, with few marrow aspirates producing IL1ra transcripts, suggests that unbalanced IL1β effects may contribute to the proliferative advantage of MDS and AML cells over their normal counterparts.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalLeukemia and Lymphoma
Volume35
Issue number3-4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Cytokines
  • Secondary hematologic disorders

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Preisler, H. D., Gao, X. Z., Ming, T., Li, B., Bi, S., Devemy, E., Loew, J., & Raza, A. (1999). Marrow cytokine transcripts and the secondary hematologic disorders. Leukemia and Lymphoma, 35(3-4), 297-302. https://doi.org/10.3109/10428199909145733