Massive ovarian enlargement in primary hypothyroidism

Keith A. Hansen, Sandra P.T. Tho, Mark Hanly, Richard W. Moretuzzo, Paul G. McDonough

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To report a case of ovarian cyst formation and myxedematous infiltration of the ovary in a subject with primary hypothyroidism. Design: Retrospective case report. Setting: University hospital. Patient(s): A 16- year-old female adolescent with pelvic pain, galactorrhea, irregular menses, and ovarian cysts on pelvic examination. Intervention(s): Laparotomy with bilateral ovarian wedge resection and thyroid replacement therapy. Main Outcome Measure(s): Ovarian histopathology, thyroid function tests, and menstrual history. Result(s): Resolution of patient's pain, galactorrhea, and resumption of normal menses. Conclusion(s): Ovarian cyst formation may accompany primary hypothyroidism in the child with accelerated or delayed sexual maturation. To date, the underlying pathophysiology of the morphological changes in the ovary remain enigmatic. This case report provides the first insight into the actual histologic changes that occur in ovaries of subjects with primary hypothyroidism without secondary ovarian pathology such as torsion. There is clear evidence of myxedematous infiltration into the ovarian stroma without luteinization of the theca interna. These microscopic findings suggest that local changes occurring independent of gonadotropin stimulation may contribute significantly to altered morphology of the ovaries in primary hypothyroidism.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalFertility and sterility
Volume67
Issue number1
DOIs
StatePublished - Jan 1 1997

Fingerprint

Hypothyroidism
Ovarian Cysts
Ovary
Galactorrhea
Menstruation
Luteinization
Theca Cells
Thyroid Function Tests
Sexual Maturation
Gynecological Examination
Pelvic Pain
Gonadotropins
Laparotomy
Thyroid Gland
Outcome Assessment (Health Care)
Pathology
Pain
Therapeutics

Keywords

  • Myxedematous infiltrate
  • hypothyroidism
  • levothyroxine
  • ovarian cysts

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Hansen, K. A., Tho, S. P. T., Hanly, M., Moretuzzo, R. W., & McDonough, P. G. (1997). Massive ovarian enlargement in primary hypothyroidism. Fertility and sterility, 67(1), 169-171. https://doi.org/10.1016/S0015-0282(97)81876-6

Massive ovarian enlargement in primary hypothyroidism. / Hansen, Keith A.; Tho, Sandra P.T.; Hanly, Mark; Moretuzzo, Richard W.; McDonough, Paul G.

In: Fertility and sterility, Vol. 67, No. 1, 01.01.1997, p. 169-171.

Research output: Contribution to journalArticle

Hansen, KA, Tho, SPT, Hanly, M, Moretuzzo, RW & McDonough, PG 1997, 'Massive ovarian enlargement in primary hypothyroidism', Fertility and sterility, vol. 67, no. 1, pp. 169-171. https://doi.org/10.1016/S0015-0282(97)81876-6
Hansen KA, Tho SPT, Hanly M, Moretuzzo RW, McDonough PG. Massive ovarian enlargement in primary hypothyroidism. Fertility and sterility. 1997 Jan 1;67(1):169-171. https://doi.org/10.1016/S0015-0282(97)81876-6
Hansen, Keith A. ; Tho, Sandra P.T. ; Hanly, Mark ; Moretuzzo, Richard W. ; McDonough, Paul G. / Massive ovarian enlargement in primary hypothyroidism. In: Fertility and sterility. 1997 ; Vol. 67, No. 1. pp. 169-171.
@article{15f84545e73c44d0b2336a3db76ee491,
title = "Massive ovarian enlargement in primary hypothyroidism",
abstract = "Objective: To report a case of ovarian cyst formation and myxedematous infiltration of the ovary in a subject with primary hypothyroidism. Design: Retrospective case report. Setting: University hospital. Patient(s): A 16- year-old female adolescent with pelvic pain, galactorrhea, irregular menses, and ovarian cysts on pelvic examination. Intervention(s): Laparotomy with bilateral ovarian wedge resection and thyroid replacement therapy. Main Outcome Measure(s): Ovarian histopathology, thyroid function tests, and menstrual history. Result(s): Resolution of patient's pain, galactorrhea, and resumption of normal menses. Conclusion(s): Ovarian cyst formation may accompany primary hypothyroidism in the child with accelerated or delayed sexual maturation. To date, the underlying pathophysiology of the morphological changes in the ovary remain enigmatic. This case report provides the first insight into the actual histologic changes that occur in ovaries of subjects with primary hypothyroidism without secondary ovarian pathology such as torsion. There is clear evidence of myxedematous infiltration into the ovarian stroma without luteinization of the theca interna. These microscopic findings suggest that local changes occurring independent of gonadotropin stimulation may contribute significantly to altered morphology of the ovaries in primary hypothyroidism.",
keywords = "Myxedematous infiltrate, hypothyroidism, levothyroxine, ovarian cysts",
author = "Hansen, {Keith A.} and Tho, {Sandra P.T.} and Mark Hanly and Moretuzzo, {Richard W.} and McDonough, {Paul G.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S0015-0282(97)81876-6",
language = "English (US)",
volume = "67",
pages = "169--171",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Massive ovarian enlargement in primary hypothyroidism

AU - Hansen, Keith A.

AU - Tho, Sandra P.T.

AU - Hanly, Mark

AU - Moretuzzo, Richard W.

AU - McDonough, Paul G.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Objective: To report a case of ovarian cyst formation and myxedematous infiltration of the ovary in a subject with primary hypothyroidism. Design: Retrospective case report. Setting: University hospital. Patient(s): A 16- year-old female adolescent with pelvic pain, galactorrhea, irregular menses, and ovarian cysts on pelvic examination. Intervention(s): Laparotomy with bilateral ovarian wedge resection and thyroid replacement therapy. Main Outcome Measure(s): Ovarian histopathology, thyroid function tests, and menstrual history. Result(s): Resolution of patient's pain, galactorrhea, and resumption of normal menses. Conclusion(s): Ovarian cyst formation may accompany primary hypothyroidism in the child with accelerated or delayed sexual maturation. To date, the underlying pathophysiology of the morphological changes in the ovary remain enigmatic. This case report provides the first insight into the actual histologic changes that occur in ovaries of subjects with primary hypothyroidism without secondary ovarian pathology such as torsion. There is clear evidence of myxedematous infiltration into the ovarian stroma without luteinization of the theca interna. These microscopic findings suggest that local changes occurring independent of gonadotropin stimulation may contribute significantly to altered morphology of the ovaries in primary hypothyroidism.

AB - Objective: To report a case of ovarian cyst formation and myxedematous infiltration of the ovary in a subject with primary hypothyroidism. Design: Retrospective case report. Setting: University hospital. Patient(s): A 16- year-old female adolescent with pelvic pain, galactorrhea, irregular menses, and ovarian cysts on pelvic examination. Intervention(s): Laparotomy with bilateral ovarian wedge resection and thyroid replacement therapy. Main Outcome Measure(s): Ovarian histopathology, thyroid function tests, and menstrual history. Result(s): Resolution of patient's pain, galactorrhea, and resumption of normal menses. Conclusion(s): Ovarian cyst formation may accompany primary hypothyroidism in the child with accelerated or delayed sexual maturation. To date, the underlying pathophysiology of the morphological changes in the ovary remain enigmatic. This case report provides the first insight into the actual histologic changes that occur in ovaries of subjects with primary hypothyroidism without secondary ovarian pathology such as torsion. There is clear evidence of myxedematous infiltration into the ovarian stroma without luteinization of the theca interna. These microscopic findings suggest that local changes occurring independent of gonadotropin stimulation may contribute significantly to altered morphology of the ovaries in primary hypothyroidism.

KW - Myxedematous infiltrate

KW - hypothyroidism

KW - levothyroxine

KW - ovarian cysts

UR - http://www.scopus.com/inward/record.url?scp=0031019506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031019506&partnerID=8YFLogxK

U2 - 10.1016/S0015-0282(97)81876-6

DO - 10.1016/S0015-0282(97)81876-6

M3 - Article

C2 - 8986704

AN - SCOPUS:0031019506

VL - 67

SP - 169

EP - 171

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 1

ER -