Mast cell leukemia (MCL): Clinico-pathologic and molecular features and survival outcome

Preetesh Jain, Sa Wang, Keyur P. Patel, Nawid Sarwari, Jorge Cortes, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Mast cell leukemia (MCL) is a very rare subtype of systemic mastocytosis (SM). We have identified 13 such patients (5.9%) among 218 patients with SM seen at our institution between 1994 and 2016. Patients with MCL had poor survival (median 31.6 months); response to various therapies was rare and not durable. Clinical course may be affected by concurrent associated hematologic neoplasm and different genetic profiles. More research is required to decipher this rare and enigmatic SM subtype.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalLeukemia Research
Volume59
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • Mast cell leukemia
  • Systemic mastocytosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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