Material Specific Learning During Electrical Stimulation of the Human Hippocampus

Gregory P. Lee, David W. Loring, Joseph R. Smith, Herman F. Flanigin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Material specific learning was assessed during unilateral electrical stimulation of the hippocampus through intracerebrally implanted electrodes in 30 patients with unilateral temporal lobe epilepsy (TLE). Verbal learning significantly decreased in patients with right TLE after stimulation of the left, but not the right, hippocampus. No verbal learning impairment was observed in left TLE patients following stimulation of either hippocampus. Visuospatial memory performance significantly decreased following stimulation of the right hippocampus regardless of the side of seizure onset. Results suggest that the contralateral “nonepileptic” hippocampus does not assume the material specific mnestic functions of the dysfunctional hippocampus associated with longstanding epilepsy.

Original languageEnglish (US)
Pages (from-to)433-442
Number of pages10
JournalCortex
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1990

Fingerprint

Electric Stimulation
Hippocampus
Learning
Temporal Lobe Epilepsy
Verbal Learning
Implanted Electrodes
Patient Rights
Epilepsy
Seizures

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Material Specific Learning During Electrical Stimulation of the Human Hippocampus. / Lee, Gregory P.; Loring, David W.; Smith, Joseph R.; Flanigin, Herman F.

In: Cortex, Vol. 26, No. 3, 01.01.1990, p. 433-442.

Research output: Contribution to journalArticle

Lee, Gregory P. ; Loring, David W. ; Smith, Joseph R. ; Flanigin, Herman F. / Material Specific Learning During Electrical Stimulation of the Human Hippocampus. In: Cortex. 1990 ; Vol. 26, No. 3. pp. 433-442.
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