Maternal Alcohol Ingestion and Blood Cord IgE Concentrations

Mary Grzybowski, Dennis R. Ownby, Christine C. Johnson, Edward L. Peterson

Research output: Contribution to journalArticle

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Abstract

Previous reports have implicated maternal ethanol ingestion as a cause of immunoglobulin abnormalities in children. We investigated the relationship between self-reported alcohol ingestion in 98 women during pregnancy and serum cord Immunoglobulin E (IgE). We found that mean cord IgE concentrations were significantly lower among newborns born to drinking mothers (0.15 IU/ml) than nondrinking mothers (0.27 IU/ml), p < 0.05. The difference of serum cord IgE means remained significant among infants with a positive family history of allergic disease, 0.15 IU/ml for infants of drinking mothers and 0.40 IU/ml of nondrinking mothers. There was a significant trend for lower mean cord IgE with increasing ethanol ingestion (p < 0.05). Maternal alcohol drinking should be considered a potential influence on cord blood IgE concentrations at birth.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalPediatric Asthma, Allergy and Immunology
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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